DO what you can,with what you have

do A with B = 用 B 做 A
do what you can 做你所能
with what you have 用你所有
放在一起：
以你所有,做你所能
也就是说
在你所处的位置,用你所有的资源,做你力所能及的事

这里的with采用的“用”这个意思,比如
We see with our eyes

DO what you can,with what you have
以上是 do sth with sth 用什么东西做什么事情一个延伸
We all eat with chopsticks
Do what you can with what you have
用你所有东西来做你所能做的事情.