英语翻译Key events are the activation and transformation of quie

英语翻译
Key events are the activation and transformation of quiescent hepatic stellate cells into myofibroblast-like cells with the subsequent up-regulation of proteins such as α-smooth muscle actin,interstitial collagens,matrix metalloproteinases,tissue inhibitor of metalloproteinases,and proteoglycans.
求翻译,能帮忙指出with thesubsequent的with怎么翻译好吗.
还有这是我翻译的请帮忙改下,专业词汇可不用修改.
中心事件是肝星状细胞（HSC）活化和转化成肌成纤维样细胞,并随后上调如α-平滑肌肌动蛋白,间质胶原,基质金属蛋白酶,金属蛋白酶抑制剂和蛋白多糖等蛋白质.