despite of /regardless of

两者搭上of后都是介系词, 使用方式没有区别. 都是介系词 + n.
有差异的部分是是词语的意思:
1. Regardless - 不管A或B, 我都会做我要做的事.
I will watch the big bang thory regardless of having dinner ot not.
不管我有没有吃晚餐, 我都会看生活大爆炸. 感觉多用于未来式.
2. Despite - 尽管, 就算是. 就算是事情已经发生了, 我还是会做.
Despite of having a empty stomach, I watch the big bang theory.
尽管我肚子饿, 我还是看生活大爆炸. 感觉多用于现在式或过去式.

不一样
despite prep.不管,尽管
如：Despite all our efforts we still lost the game.
尽管我们尽了全力,我们还是输掉了比赛.
despite of相当于形容词,在用法中当形容词用.
如：The boys went for a walk despite of the rain.
尽管下雨,孩子们还是去散步.

despite是介词,例如：
He keeps smokimg despite her objection.
in despite of 是介词词组,意思与in spite of一样,但是in despite of 这个词组的in 可以省略.例如：
He works hard (in) despite of poor health.

首先搞清几个词和短语的用法:
despite 尽管;虽然(是介词,后跟名词或代词,构成介词短语)
Despite the difficulties he threw himself into the research.
尽管困难重重,他还是全身心投入了调查研究.
despite all that尽管如此 (作状语,要用逗号与句子的主干隔开)
Despite all that,tourism is still making modest progress.
尽管如此,旅游业依然有适度的发展.
despite of没有这个短语,应为:
in despite of 尽管
We started for the tour in despite of the heavy rain.
尽管下大雨,我们还是出发去旅行.
We shall be victorious in despite of difficulties.
不管有什么困难,我们一定会胜利.
没有in spite that的说法.应为:
in spite of不管,不顾；尽管,虽然 (in despite of =in spite of )
He has modern ideas in spite of his great age.
尽管他年事很高,但思想观念却很入时.
In spite of the rain he was insistent on going out.
尽管下雨,他仍然坚持外出.
再来分析问题中这个句子:
AC选项的短语本身就不正确,首先排除; D选项没有逗号,且用在此处,句意不通.
故选B.Despite
句意:尽管现代马戏团偶尔有意外的暴力事件,但它与很久之前的野蛮的同名物几乎没有关联.

完全是一样的意思,后面一般跟ing形式,despite of/in spite of （doing） sth,用于句首句中都可以.像一楼说的although只用于句首,且后面接句子.而和它同意的though句首句中都可以.以上四个都是同义词.

没有despite of,只有inspite of ."despite"后面接的一定是名词,例子：Despite all our efforts ,we still lost the game.尽管我们做了全部的努力,但还是输了游戏."inspite of"后面也是名词,例子：inspite of all our...

despite=（in ）despite of=in spite of
尽管；不顾,都跟单词或者短语.
例如：He went out despite (of ) the heavy rain.
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in spite of 、despite of 和 despite 都可以表示“不管…,尽管…”的意思,in spite of和despite of是介词短语,后面跟名词、介词、动名词；而despite是个连词,后面跟的是句子.The boys went for a walk despite of t...