β-内酰胺类与氨基糖苷类抗生素联合应用机制

落叶绯绯2022-10-04 11:39:541条回答

β-内酰胺类与氨基糖苷类抗生素联合应用机制
β-内酰胺抗生素与氨基糖苷类抗生素协同作用机理,

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乱了的淡蓝色忧郁共回答了26个问题 | 采纳率88.5%: β-内酰胺抗生素抑制细菌细胞壁合成,属于繁殖期杀菌剂；氨基糖苷类抑制细菌蛋白质合成,属于静止期杀菌剂.两药连用具有协同作用.

但是上述只是理论上,实际上临床上无法将两类药物配伍在一起,氨基糖苷类的糖氨基与β-内酰胺环交联断裂生成氨基酰胺化合物而失活,所以不可将两类药物混合注射.另有研究发现,测定氨基糖苷类血药浓度时,血浆中的β-内酰胺类抗菌药物仍可灭活氨基糖苷类药物,使其浓度降低.基于上述发现,国外资料建议两类药物联用时,给药时间应间隔1小时以上,以保护氨基糖苷类药物的活性.; 1年前

寻高手帮忙翻译成英文结果：I类切口手术预防用药率达100％,使用抗菌药物频度居前3位的为其它β-内酰胺类（头孢西丁和头孢 寻高手帮忙翻译成英文 结果：I类切口手术预防用药率达100％,使用抗菌药物频度居前3位的为其它β-内酰胺类（头孢西丁和头孢美唑）(92例次)、喹诺酮类(77例次)、青霉素类(71例次)、林可胺类(60例次)；用药时间主要在术后,最短1 d,最长20 d,平均用药时间5.4 d；单一用药占68.0％,二联用药占28.8％,三联及三联以上用药占3.2％.抗菌药物占药物费用的平均比率是25．22％. 结论：I类手术预防使用抗茵药物存在较多问题,经过对其监测,逐渐规范了使用,但仍有待提高.随着抗生素的大量使用,细菌耐药性不断发展,I类切口围手术期抗菌药物预防应用需严格掌握用药指征,药物的选择及用药时间应遵守《抗菌药物临床应用指导原则》合理使用. chanhoipan1年前1: 吟子共回答了19个问题 | 采纳率100%

Results: I type incision surgery is 100% prevention of drug use, frequency of use of antimicrobial drugs among the top three for the other β-lactam (cefoxitin and cefmetazole) (92 cases), quinolones (77 cases times), penicillin (71 cases), Lim amine (60 cases); drug mainly in the postoperative time, minimum 1 d, up to 20 d, the average medication time 5.4 d; single drug accounted for 68.0%, 2 agents was 28.8%, more than triple and the triple drug accounted for 3.2%. Antimicrobial drug costs accounted for the average rate is 25.22%.
Conclusion: I types of surgery to prevent use of antibiotic drugs in the existing problems, through its monitoring, gradually standardize the use of, but still be improved. With the extensive use of antibiotics, bacterial resistance growing, I Types Incisions Perioperative application of antimicrobial agents should be careful indications, drug selection and time of medication should comply with "guiding principles of clinical application of antibacterial" fair use.给点分吧

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β-内酰胺类与氨基糖苷类抗生素联合应用机制

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