barriers / 阅读 / 详情

英语作文:谈谈对广告的看法

2023-06-25 07:13:24
共2条回复
S笔记

My Opinion on Advertisement

As is known to all, angels and evils are poles apart. But is there anything that combines the two perfectly? Some there is-the advertisement. With the growing influence of mass media, advertising invades every aspect of our lives. Whenever we turn on the TV, look through a newspaper, open the mailbox, or surf on the Internet, advertisements would immediately jump into our sight. As they make things so attractive, we often end up buying things that we do not really need. Advertising not only adds to the price of the goods, thus harming the consumer"s interest, but also imposes a kind of materialistic value upon the audience. But that is only part of the story-advertisements are informative as well as persuasive. They provide us with up-to-date information about the latest products. Some advertisements are so elegantly presented that we are inspired or even moved. No matter it is an evil or an angel, advertisement has become an indispensable part of our modern life.

meira

Advertisement is misleading. Take for example, the sex enhansing medication, the advertisement will boast that it will lengthen the penis and enlarge it diameter. The advertisement will also bullshit that there is no side effect to the medication. There will also there to put in many fake references of people who had used the medicaion before. These collaborators will bullshit that their penises will lengthen by five to ten cenimetres or the diameter had increased to four centimetres. So such a fantastic medication, will you try?

相关推荐

发音为“皮呢斯”的单词是什么意思

penis 英[u02c8pi:nu026as] 美[u02c8pinu026as] n. 阴茎,阳物; [例句]You let me talk to you about his penis.你居然让我和你讨论他的小弟弟。[其他] 复数:penises
2023-06-25 03:55:011

阴茎的英文怎么写

Penis,,,,,,,,,,,,,
2023-06-25 03:55:105

penis是什么意思?

penis的意思:阳物,[解剖] 阴茎。读音为:英 [u02c8piu02d0nu026as]、美 [u02c8piu02d0nu026as]。复数形式为: penises或penes。例句:1、Over time, blood vessels and nerves in the penis can becomedamaged.随着时间的推移,阴茎中的血管和神经会被破坏。2、The doctor will put a numbing medicine gel on the penis.医生将在阴茎上涂敷胶体麻醉药。相关故事有一些人家,准备日后将自己的孩童送进宫当太监,在襁褓之中,就由特种佣妇带,用她的巧妙手术,扭捏婴孩下身,令婴孩的生殖器渐渐萎缩,把天然的机能完全毁灭。从小就把他送入宫闱,同年幼太子和公主做伴嬉戏。这种儿童太监,日后极有可能在发育期中,得到生理上的天然力量,恢复他的性机能。要是与小太子已亲若兄弟,那么宫中的检验太监也不敢再予以细察,这是玉茎重生出于天然的因素之二。
2023-06-25 03:55:231

“笔直的”用英语怎么说?

谐音是 “死最他”
2023-06-25 03:55:411

How many penises do you have?

你又多少便士,是penies
2023-06-25 03:56:123

请问,Love-muscle是什么意思,谢谢

爱情力量?
2023-06-25 03:56:204

各位大侠,帮帮忙啊,急求关于老虎和狮子的资料,只要英文的。

Tiger tiger tiger), (cat-like animals, is also the most powerful Asian terrestrial predators, is one of Asia"s existing today the top predators, the tiger has one of the longest canine cat-like animals, most large claws, it gathers speed strength agile at a suit, a swinging strength of selenarctos 1000KG, claws penetrated depth of 11 cm, a hopping long can reach 6 meters, is the most perfect predators adult tigers can reach four metres long and weighs 350 kilograms. In its huge body shape and powerful muscles besides, they most conspicuous features, is in white to orange fur with black stripes, they vertical the lower part of the lighter colorLions (the lion) is the only type of male and female two states of the cats is the earth powerful cats
2023-06-25 03:56:274

不求回报电影中经典台词10句

There are only two way to live your life.One,as if nothing is a miracle.The other,as if everything is a miracle.只有两种方式去度过你的一生,第一种,一生平凡,另一种,一生不凡。Wallace:You know the best part about my gay dads?They"re never gonna eat out my ex-girlfriends.瓦勒斯:你知道有同性恋爸爸的好处在哪里吗?他绝对不会睡我的前女友。Emma:You don"t have to feel embarrassed,because we"re all doctors,so we see literally hundreds of penises a week.艾玛:你不用感到尴尬,我们都是医生,我们每个礼拜要看100多哥小弟弟。I see thousands.我看1000个小弟弟。I just pulled a penis out of a VitaminWater yesterday.昨天我才把一个小弟弟从维他命水里拿出来。Emma:Use each other for sex,at all hours of the day and night .Nothing else.艾玛:只为性而利用彼此,不管是在白天还是黑夜,不谈感情。Emma:You give me premature ventricular contractions.You make my heart ship a beat.艾玛:你害我得了心室性早起收缩症,你让我的心脏漏跳了一拍。Emma:I don"t need you to take care of me.I take care of myself.That"s what I do.Why don"t you go find some other girl who"s not gonna hurt you?艾玛:我不需要你关心我,我会照顾我自己,我就是这样的,你为什么不去找那些不会伤害你的女孩?Adam:Because I love you.It"s obvious.I completely love you.亚当:因为我爱你,很明显,我完完全全地爱上你了。亚当因为爱着艾玛,却和艾玛过着有性无爱的生活。Adam:I can"t keep doing this.I"m not gonna see you again.亚当:我不能一直这样,我不会再见你了。Adam"dad:When you"re married and you do blow...try to stay away from women who want to fuck you.Even ugly women.Blow is blind.亚当的父亲:当你结婚之后,你会感到厌烦,得试着远离所有想和你睡的女人,甚至是丑女人,性是盲目的。Adam"dad:We don"t pick who we fall in love with.And it never happens like it should.亚当的父亲:我们无法控制自己会爱上谁,而且那人总是不期而遇。Emma:I don"t know why I wasted so much time pretending I didn"t care.I guess I just didn"t want to feel like this.It hurts.But I love you.I"m totally and completely in love with you,I don"t care if you think it"s too late,I"m telling you anyway.艾玛:我不知道自己为什么一直装得若无其事,我猜是因为我自己不想面对,那感觉很伤,但是我爱你,我彻彻底底爱上你了。我不在乎你绝不觉得这话说得太晚,但我现在告诉你了。Adam:You should know if you come any closer,I"m not letting you go.亚当:你应该明白,如果你再靠近一点,我就不会让你走了。
2023-06-25 03:56:351

MC光光on freestyle歌词

莫莫candy 二级 0 | 我的知道 | 消息 | 空间 | 应用 | 退出 我的知道 我的提问我的回答为我推荐的提问知识掌门人文档分享 应用 礼物投票转贴HOHO更多应用 新闻 网页 贴吧 知道 MP3 图片 视频 百科 文库 帮助 | 设置 百度知道 > 娱乐休闲 > 音乐添加到搜藏待解决 MC jin在freestyle Friday连胜7周德中文字幕 悬赏分:100 - 离问题结束还有 6 天 14 小时 MC jin在freestyle Friday 连胜7周德中文字幕我要MC jin和他的对手的中文字幕全部7周的 提问者: 卩s灬伢布 - 三级 我来回答: 第1步:输入你的答案回答即可得2分经验值,回答被采纳可同步增加经验值和财富值 您还可以输入字输入内容已经达到长度限制插入地图 插入图片 参考资料: 匿名回答 积分规则 第2步:点击提交回答 回答 共 1 条[1]JIN: jin vs hasan with a name like "hasan" you should join the talaban cause that"s the only way you"ll get flex to drop a bomb when they retire me and i land in the booth. you"ll be outside tryin to shake hands with scoop. you got six victories?i wonder if this will hurt the closest you"ll get to 7 is the numba on ya shirt yeah im chinese now you understand it .im the reason that his little sister"s eyes is slanted if you make one joke about rice or karate nypd be in chinatown searchin for your body ask free she"ll tell you to duck down he thought the harlem shake was a drink from uptown whacha want to do son? i"m ill when i spit i"m tellin you right now yo, you aint legit cause when i finish spittin 看到你那"hasan"的名字,我觉得你该加入塔利班 如此一来你就能名正言顺的制造爆炸事件了 当我退休开小摊儿的时候 没准你正在街上对狗骑兔子招手(搭便车)呢 你卫冕六周吗?告诉你个不幸的消息 你卫冕-TSHIRT上的数字顶头也就是七了 没错 我是中国人,现在你明白了吧? 是我把你妹震得嘴歪眼斜的 你小子要是敢拿大米和空手道开一个字的玩笑 横尸唐人街就是你的下场 顺便说一句,她会让你卧倒 黑人区的街头生活可不象上流社会那么悠闲 怎么着吧孙子?你丫想干吗?我不爽就要骂! 听好了!我不骂爽了还不算完! [2]JIN: jin vs sterling (notorious big - one more chance) you wanna say im" chinese sonny? here"s a reminder check your tims they probably say "made in china" don"t make me get on this tip and straight kill ya his name is sterling cause all he rocks is silver dude, you, stop followin trends your girl must love alcohol cause she be swallowin" jin yo imma bout to flip the when it"s comin" to it aye yo you see me spittin on the block you runnin to it this is 106 and park, i"m a hard act to follow you a amateur, you go to the apollo cause i"m freestyling know when i"m done son, you ain"t a baller tell the audience the truth i saw him breakdancing for spare change on 40-deuce 宝贝儿!你想取笑我是中国人,给你提个醒. 你那靴子上写着"中国制造"呐 让我一下抓住你这个错把你说得无语 你那亮闪闪的银链子比你名字拉风多了 我说哥们,别见样学样 你的妞肯定喝高了,因为她正suckin jin"s dick(就不写中文了,大伙都明白.呵呵) 我走哪你跟哪 我吐口痰你都狠不得过去舔两口 这是在106 and park,想学我可不容易 你要是个业余的就去apollo吧 我正freestyle呢,孙子,好好听着就快完了 跟观众说实话吧,你屁也不是 我看见这孙子刚才跳霹雳舞了! [3]JIN: jin vs skitzo (busta rhymes f/ p. diddy - pass the courvoisier pt ii) yo, you a sucka and i mean it kid my girl would never go with you cause she don"t like guys with small penises don"t make me have to come at you aye yo, cause as a rapper, you really don"t have a chance better off asking nelson to teach you how to dance my freestyle is about to tear you up i"m really somethin that you not use to he at first wanna open a fortune sayin you"re a loser four more weeks i"m in the hall of fame with posterboy then you can join my street team and put up posters, boy you ain"t close to me my manager"s about to get me a deal his manager"s baggin groceries claim you clap guns supersoakers make noise he the type to play strip poker with his boys 你小子是个彻头彻尾的王八蛋 我的妞永远不会找你因为你的老二尺寸太小 别逼我打你 因为我是个RAPPA,你根本没机会 还不如找nelson让他教你怎么跳舞呢 我的FREESTYLE能把你损个底儿掉 我的水平你望尘莫及 他想在开场给我难堪,结果事与愿违 再有四周我就功成名就了,小子 到时候你可以进我的队里还能沾光上海报呢,小子 你跟我没法比,我的经纪人给我签了份合同 你的呢?沿街要饭呢吧? 给丫鼓倒掌!把他嘘下台! 他也就有跟他那帮小子玩剥猪猡的能耐 [4]JIN: jin vs. logan yo, if the rap game is whack everybody"s blamin you you from brookyln? then biggie mush be ashamed of you cause imma freestyle, show you how it is matter fact, you from bk, i heard they murder things only time he see beef is when he go to burger king i"m the player in the game you cheerin in the stands matter fact, durin the superbowl, he was cheerin for the rams you don"t even like football that"s a myth like unicorns he just like seein" grown men in tight uniforms i"m freesylin when im kickin it so ridiculous, put yourself in a bad predicament by the way, my little sister has somethin to say "there"s no way you"ll beat my brother on freestyle friday!" 如果这场你输了,大伙会骂死你 你从布鲁克林来的?biggie将以你为耻 我正在FREESTYLE,让我教教你怎么做吧 你真从布鲁克林来吗?事实上,我听说过一条爆炸性新闻 他每次去”汉堡王”时,才能尝一次荤 舞台上我是老大,你只能站那给我叫好 事实上,”超级碗”杯上,他是给公羊队叫好的 你说喜欢橄榄球,真是无稽之谈,扯淡 你只不过想看看那些穿着紧身队服的壮男 当我正在FREESTYLE时发现你的RAP把你自己置于一个尴尬境地,太滑稽了 稍等,我的小妹妹有话说 ”想在freestyle friday上赢我哥哥,没门!” [5]JIN: jin vs. luck luciano uh, see, i really don"t know what you"re doin he got a kobe bryant jersey on but look more like a light-skin patrick ewing i"m nice wit it when im spittin come on, in a week or so i"ll be spittin onzz beatz while you"ll be at the bodega askin forss cheese im nice with it freestyle come on you wanna talk about guns that"s why you get your studder on only toast he packs is the kind you put butter on i"m nice with it when i free come on, yo check it out, ask your girl i was doin somethin at her house matter fact, she had my eggroll and my dumplings in her mouth next time you see her bring extra protection next time you see her it"s a rap 真不知道你想干吗?不伦不类 穿着科比的运动衫看着却像个稍微白点的帕特里克.由因 我RAP的时候很酷 再过一两周我就我的身份就更不同了 而你呢?在饭馆讨食吃吧! 我FREESTYLE时更酷 你想谈谈枪火?先把扣子系好吧. 你吃烤面包时也就抹点黄油罢了(可能是损他肚子里没词吧) 我FREESTYLE时感觉棒极了 问问你的马子在屋里和我干过什么? 事实上,她把我的蛋蛋和JIJI放在了她嘴里 下次带她出来时多加小心 下次你看见她 这是RAP????(这句莫名其妙) [6]JIN: jin vs. skazoo yo, i get girls who you tryin to dis man? he masturbate so much he had to roc a wristband you got guns pointed my way he"s so played out i thought he was the old school joint of the day i got fans across the country jin is who they feelin" last time he had a fan it was spinnin on the ceilin" i go online, and check my hotmail he go on the internet lookin for hot males you aint a hustler your man"s coppin the work he be at the club, like tweet, droppin his skirt oops, i didn"t know my freestyle teared up you up on stage but it"s a pity though don"t make me spit in your mouth like missy"s old video im nice with it 我马子成堆,你想损谁啊? 他手淫过多,袖口都脏了. 你想打败我?别费劲了, 你就是个唱OLD SCHOOL的最傻的傻大个 我的粉丝遍布全国. 你最近的一个粉丝现在再天花板上吊着呢 我上网是为了查邮件 他上网是为了找GAY 你不是拉皮条的 你的同志们在夜总会工作, 看起来就像TWEET脱裙子一样滑稽(tweet好象是那个坐椅子上的胖子) 哦!不好意思,我什么也没说,我让你在台上一败涂地 尽管你很不幸,但也别惹我,当心我像MISSY当年的MV一样吐痰在你嘴里 [7]JIN: jin vs. sean nicholas you aint a regee arist and i aint hatin on you stop lyin mrs. cleo is more jamaican than you i"m nice with it when i"m freein who you think you bein"? my pants are new my sweater is new don"t be mad at chinese kid dressed better than you man im freestylin" now its a rap, matter fact you should ask clef... how to make your flow tighter better yet, pay him 20 g"s to be your ghostwriter i"m nice when i"m freein" you ain"t beatin me matter fact i"ll be a buffet and you ain"t eatin me and don"t make me start rappin in chinese on the microphone "nei fan oak kay lah" that means take your sorry butt home! 你要不唱雷鬼我还不想骂你 别扯淡了,mrs. cleo 比你更像牙买加人 我现在骂你骂的很爽,你以为你是谁? 我的裤子是新的,运动衫也是新的 别一看中国人穿的比你好就急眼 你知道什么是RAP什么是FREESTYLE吗? 你该请教clef怎么把你的FLOW控制好 然后给他20块让他为你捉刀写词 你想打败我,别做梦了 其实你根本不是我对手 别让我用中文骂你 nei fan oak kay lah 就是说”抬起屁股滚蛋!!” ***饶舌擂台赛现场经典对战*** 你以为你是谁?李小龙? 穿着条向下掉的裤……我到这里来不可以不让我讲粗口,来肯定我是社会地位低下的黑人,我永远不会冷静下来,这是对的,因为你好像一个纸老虎,我想在你的尾巴上咬一口……喂!我没昏头……根本就不会说饶舌,还来凑热闹,饶舌不是你们中国人可以学得会的! 你不是雷鬼音乐表演家,而且我不恨你,不要讲大话啦,你是牙买加人你比我更清楚……你不能再这样愚蠢,不要跟个比你穿得好的中国人发疯……去问你老师怎么才能把裤子穿好,或者给他20块钱让他帮你写歌词……我即兴说唱时我是好人……不要让我开始用中文在麦克前骂你……要你带着遗憾回家啦!
2023-06-25 03:56:533

网络热搜词隐藏了哪些性现象?

关于性这个话题,大多数人都有些讳莫如深。但在搜索引擎关键词数据的帮助下,科学家们称他们发现了人们最想要的到底是什么。    据每日邮报报道:社会学家Ogi Ogas和Sai Gaddam在研究了10亿条谷歌以及其他搜索引擎上关于性的搜索词条之后,将其发现忠实记录在了其新书《十亿邪念(A Billion Wicked Thoughts)》中。两人称通过分析数据发现以下几个现象:    男性其实更爱有肉的女性,而不是苗条款的。  说到具体的人体部位,大部分男性觉得最性感顺序依次是胸、臀、脚。这一顺序对同性恋和异性恋男性都同样成立。  异性恋女性对男男之爱非常有兴趣,但其关心的重点并非性而是两人间的情感互动。  跟女性比,男性更喜欢幻想群交,而且是男性人数多于女性的那种。  异性恋男性最爱看网友自制的A片  异性恋女性和同性恋男性都爱看SM类型  同性恋男性也喜欢看男女A片    两人发现,互联网上八成的搜索都是关于20个关键词,而搜索量最高的前十个“邪念”则是:  Youth-青年 (13.5%)  Gay -同志(4.7%)  MILFs -性感人母(4.3%)  Breasts -胸(4%)  Cheating wives-出轨人妻 (3.4%)  Vaginas-阴道 (2.8%)  Penises-阴茎 (2.4%)  (Blocked out in the book)书中隐去  Butts-臀 (0.9%)  Cheerleaders-拉拉队员 (0.1%)    不过也有专家认为,通过统计搜索关键词的方法并不能证明最能让人们“性致勃勃”的就真的是这些内容,很有可能只是出于好奇。美国进化心理学家Donald Symons在接受纽约邮报采访时说:“书作者认为人们搜什么就是对什么有性趣,这个观点我不同意。要是有个色情片女星长着三个乳房,我敢打赌也会吸引很多搜索量。这是否就能说男性突然喜欢三乳呢?我不这么认为。”    但该书的作者则表示已经充分考虑到了好奇才搜索的情况,但他们发现不少人会在搜索之后花钱注册相关网站,并且重复浏览,这就说明这些并不仅仅是出于好奇的搜索。
2023-06-25 03:57:011

英文讲课开场白

  英语开场白【一】   既然是英语课,就应该有一个“带有英语”的开场白。走进教室后,我一边招手一边面带笑容的用英语和学生说“Hello! Boys andgirls!”   并简单介绍“Iu2019m your new English teacher.You can call me MissYan"然后互相用”Hello!"打招呼,这个时候学生还有些胆怯,不能完全放开,我就竖起大拇指略微夸张的表扬他们:"Verygood!"“Hownice!"进一步打消他们对英语的畏惧感,并且让学生在第一时间领略到英语的风采。   虽然很多英语学生不能听懂,但是学生越是听不懂,就越想知道是什么意思,这样就越能激发学生对英语的好奇和兴趣。   当然,需要注意的是,教师也不能只顾着展示“风采”,不管学生是否明白,这样,时间一长,学生就会觉得疲劳、索然无味。因此,教师在说的"同时要配以相应的体态语言,帮助学生理解意思。总而言之,第一节英语课必须用英语作为开场白,激发学生学习的欲望。   英文讲课开场白【二】   Opening Statement   mr. chairman, senator thurmond, members of the committee, my name is anita f. hill, and i am a professor of law at the university of oklahoma. i was born on a farm in okmulgee county, oklahoma, in 1956. i am the youngest of 13 children. i had my early education in okmulgee county. my father, albert hill, is a farmer in that area. my mother"s name is irma hill. she is also a farmer and a housewife.   my childhood was one of a lot of hard work and not much money, but it was one of solid family affection, as represented by my parents. i was reared in a religious atmosphere in the baptist faith, and i have been a member of the antioch baptist church in tulsa, oklahoma, since 1983. it is a very warm part of my life at the present time.   for my undergraduate work, i went to oklahoma state university and graduated from there in 1977. i am attaching to this statement a copy of my resume for further details of my education.   i graduated from the university with academic honors and proceeded to the yale law school, where i received my jd degree in 1980. upon graduation from law school, i became a practicing lawyer with the washington, dc, firm of ward, hardraker, and ross.   in 1981, i was introduced to now judge thomas by a mutual friend. judge thomas told me that he was anticipating a political appointment, and he asked if i would be interested in working with him. he was, in fact, appointed as assistant secretary of education for civil rights. after he had taken that post, he asked if i would become his assistant, and i accepted that position.   in my early period there, i had two major projects. the first was an article i wrote for judge thomas" signature on the education of minority students. the second was the organization of a seminar on high-risk students which was abandoned because judge thomas transferred to the eeoc where he became the chairman of that office.   during this period at the department of education, my working relationship with judge thomas was positive. i had a good deal of responsibility and independence. i thought he respected my work and that he trusted my judgment. after approximately three months of working there, he asked me to go out socially with him.   what happened next and telling the world about it are the two most difficult things -- experiences of my life. it is only after a great deal of agonizing consideration and sleeplenumber -- a great number of sleeplenights tha(t i amable to talk of these unpleasant matters to anyone but my close friends.   i declined the invitation to go out socially with him and explained to him that i thought it would jeopardize what at the time i considered to be a very good working relationship. i had a normal social life with other men outside of the office. i believed then, as now, that having a social relationship with a person who was supervising my work would be ill-advised. i was very uncomfortable with the idea and told him so.   i thought that by saying no and explaining my reasons my employer would abandon his social suggestions. however, to my regret, in the following few weeks, he continued to ask me out on several occasions. he pressed me to justify my reasons for saying no to him. these incidents took place in his office or mine. they were in the form of private conversations which would not have been overheard by anyone else.   my working relationship became even more strained when judge thomas began to use work situations to discuse-x. on these occasions, he would call me into his office for reports on education issues and projects, or he might suggest that, because of the time pressures of his schedule, we go to lunch to a government cafeteria. after a brief discussion of work, he would turn the conversation to a discussion of se-xual matters.   his conversations were very vivid. he spoke about acts that he had seen in pornographic films involving such matters as women having se-x with animals and films showing group se-x or rape scenes. he talked about pornographic materials depicting individuals with large penises or large breasts involved in various se-x acts. on several occasions, thomas told me graphically of his own se-xual prowess.   because i was extremely uncomfortable talking about se-x with him at all and particularly in such a graphic way, i told him that i did not want to talk about these subjects. i would also try to change the subject to education matters or to nonse-xual personal matters such as his background or his beliefs. my efforts to change the subject were rarely successful.   throughout the period of these conversations, he also from time to time asked me for social engagements. my reaction to these conversations was to avoid them by eliminating opportunities for us to engage in extended conversations. this was difficult because at the time i was his only assistant at the office of education -- or of   fice for civil rights.
2023-06-25 03:57:101

谁能帮忙写个题目为《all man are born equal》的英语作文?

all man are born equal As it is written in every civil country"s constitution, everyone is equal, no matter whether they"re healthy or unhealthy, black or white, men or women. First, I want to say that disabled people are equal to normal people. We should not look down on them. It"s not their fault for being disabled; they were created this way or some accidents tool their abilities away. Despite all the inconveniences they face, the} can also achieve success if they are recognized and respected as equal and given equal chances. Helen Keller, a famous American writer, was a person that I"ve always looked up to. She was born blind, deaf and mute, thus she could not see or hear or learn to speak. She was treated like an animal in a complete darkness and loneliness when she was young, until one day, Miss Ann Sullivan, a teacher from Boston, came to her, loved her with all her heart, taught her and helped her to succeed. And Helen accomplished so many things that even normal people couldn"t with the help of Ann. So why don"t we all lend a hand to those who are in need of our help, instead of looking down upon them? Remember that we"re equal. Second, black people are equal to white people. There was a sad time in history when blacks were used as animal labor, sepa-rated from their parents or children, traded and shipped in filthy ships to places unknown but dreadful to them. But that was so unfair and wrong! They"re really not "black meat "as they were called. They are human beings with feelings and emotions and in-telligence like every one of us and every white person! Look, who is Secretary General of the UN today? Doesn"t Mr. Kofi Annan work just as well as or even better than white people? The great black movement leader, Martin Luther King Jr. once said, "I have a dream, that one day, on the red hills of Georgia, the sons of former slaves and the sons of former slave owners will be able to join hands and sit at the table of brotherhood. " It is also my dream that people will no longer be concerned by their petty dif-ferences and stand on equal ground! Last, I want to say that women are equal to men. If there is anyone who would argue that men are superior to women, please let him answer why there has never been a male scientist in human history to do a better job than Madam Curie who won the Nobel Prize twice? We have to admit that men and women are different and good at different things. But that"s it, and that has nothing to do with who is better or who is worse. We should all see this truth. Today we still need to make more efforts to realize this. Only in this way will we make this world a much much better family for all of us! ------------------------------ ------------------------------ ------------------------------ -------- why it"s better to be a woman Several months ago, my friend Chip wrote an essay entitled, Why It"s Better to Be a Man . While it included a few convincing arguments (men don"t have to carry purses; men have less to shave), I was disappointed he could only come up with 10 reasons. After all the time I"ve spent listening to men rave about their units — not to mention enduring the phallic homages played out in skyscrapers, modern art and heavy metal — you would think there would be more than 10 lousy reasons. I can think of 10 reasons not to long for what the boys got: 1. Women Get to Wait in Line at Public Restrooms This might seem like an argument for the opposite camp, but think of the times you"ve been at a baseball game or monster truck pull having a perfectly miserable time with a male companion. By excusing yourself to stand on line at the biffy, you were reunited with many of your own gender, and as you inched forward, flush after flush, you began to talk — really talk — with these women (shared discomfort creates deep trust and mutual understanding). By the time you made it to the stall you were hugging your companions goodbye and exchanging phone numbers — friends for life! Men, on the other hand, are in and out of the head in no time. Do you think it"s a coincidence that men have difficulty creating close and lasting friendships with other men? 2. Women Get a Door This is related to reason one. There"s something unseemly about having to pull out your goods for public display, and ... horrors, I can"t even go on! 3. Women Get to Sit Down There"s been some controversy on this topic, thanks to Camille Paglia, who writes in her book Sexual Personae: "Male urination is a kind of accomplishment, an arch of transcendence. A woman merely waters the ground she stands on." I can"t speak for Camille, but only in extreme cases of toilet deprivation have I ever "watered the ground I stood on." I prefer to sit. 4. Men Make More Money Men, propelled by their willies and some prehistoric hunt-and-gather mindset, spend their nasty lives clawing, sniping and scratching their way to the top of the pay scale, all the while eating fatty foods, losing their hair and clogging their arteries, until one day — kablooey! — they keel over. When they"re gone, it"s the women (who live longer) who spend what"s left. All those old ladies you see at the travel agency collecting stacks of cruise brochures are having fun, fun, fun! 5. Women Never Worry About Whose is Bigger No matter what we tell men about how much size doesn"t matter, it does. (Well, it doesn"t really, but we talk about it with our girlfriends, anyway.) Knowing this, women can feel fortunate that we don"t attach much of our identity to something we can only see in a hand-held mirror. 6. Women Are Better Looking Because women don"t have penises, and therefore, loads of violence-inducing testosterone coursing through our veins, we"re prettier, softer, have less stubbly black hair, smell better, and are basically more lovely to behold. When men can"t understand why we spend so much time in the bathroom, it"s because they don"t know the joy of appreciating one"s lovely mug in the mirror. 7. Women Have Breasts Given the preoccupation that straight men have with these, it puzzles me that Freud never came up with a Breast Envy theory. Breasts are fun, no matter what shape, size or agenda, be it nutritional or recreational. They are soft, reassuring, and in their passive splendor, a far more potent sexual asset than any dangling penis. 8. Women Have Periods As a woman, I am allowed to eat copious amounts of food, yell at my loved ones, cry uncontrollably for no reason, and when it"s all over, say "I can"t help it. I"m having my period." When men behave this irrationally, which they are known to do, they have no excuse. 9. Women Bear Children Men and their equipment make an important contribution to the reproductive cycle, but their role is much like that of the center on a football team: He hikes the ball, she carries it for a touchdown. Being pregnant might be more of a burden if it weren"t for the fact that men suffer so much more seeing what their seed has done to the women they love. Labor pains are brief compared to the torment you can inflict on a man just by smiling weakly and saying, "That"s OK, honey. I"m sure you would have been glad to carry Junior, if only you could." 10. Women Have a Hidden Agenda You can"t play hard to get when your intentions are standing at attention. You know what I"m talking about — the pleading eyes, the heaving chest, the sudden alertness in his nether regions — it"s so obvious, for God"s sake. For women, it is a blessing to be able to withhold some cards from the sexual table, thus creating a sense of mystery and promise. Think of it as hiding one"s light under a bushel.采纳哦
2023-06-25 03:57:171

谁能把 中国人的那段英文写出来 就是中国人jin唱的即兴的rap的词写出来 谢谢哈

你不是雷鬼音乐表演家,而且我不恨你,不要讲大话啦,你是牙买加人你比我更清楚……你不能再这样愚蠢,不要跟个比你穿得好的中国人发疯……去问你老师怎么才能把裤子穿好,或者给他20块钱让他帮你写歌词……我即兴说唱时我是好人……不要让我开始用中文在麦克前骂你……要你带着遗憾回家啦!
2023-06-25 03:57:252

clusterfuck是什么意思?

没有这个英文单词
2023-06-25 03:57:343

美国论坛里白人女人怎么看亚洲男人?

在美国,跨族婚姻很普遍。与亚洲人通婚的白人多是男人和亚洲女人在一起,而亚洲男人同白人女人在一起的例子不是很多。从这些白人女性所讨论的内容来看,白人女性对亚洲男人还是有好感的,但也有一些偏见。比如说,身才不够高大,性方面不能满足白种女人,脾气不好,老一辈对儿女干涉太多,宗教不同,下一代教育问题等等。比较严重的偏见是在性方面。一是亚洲男人的SIZE不够,二是亚州男人对性的过分要求。难听点儿说,就是性心有余而性力不足。但这两点,对于同亚洲男人有性经验的白人女人来说,都是不成立的。她们都同意,跨族婚姻最重要的还是要看两个人的感情,这一点,可以看出天下女性的宽容谦让的共性和对感情方面和睦的追求。 以下是在一个美国网站的论坛上,一个在和中国男人恋爱的犹太姑娘发贴而引起的讨论。她想知道其他人对白人女性同亚州男性相处有什么看法。回贴的人很多,有白人,黑人,拉美人,还有在北美出生的亚洲男性和女性。因篇幅太多,只选择一些有代表性的白人女ID回贴。 比较有意思的是一个俄罗斯姑娘PINKLACES的回贴,文中透露出她对亚州男人说到做到的欣赏和对学校里美国男生乱搞和亚州女生乱睡的鄙视。 还有一个有趣的现象是一些在北美出生的亚洲男孩和从移民来的亚洲姑娘的态度。因篇幅太长,没有登在这里。但他们的观点很有意思。这些在北美出生的亚裔男生回贴中反复强调他们是如何与其他亚洲男人不同,他们是如何身强力壮,只喜欢白人女孩,不喜欢亚洲女孩。他们认为因为他们和白人女孩生长在一起,容易沟通。而亚洲女孩太懦弱,听话,没主见。 Luv2Me [more]IP: Logged Posts: 14 Group: New Member Joined: Aug 2002 Status: OFFLINEMake Buddy | PM User Hi there. I"m currently in my first interracial relationship. I"m white and Jewish, and I"m dating a Chinese guy. We have a lot in common... in fact, I"m taking Mandarin Chinese (unfortunately he speaks Cantonese, but no matter) and started even before I met him. I"m studying East Asian Studies in university, and so is he. We"ve got a lot in common, and my parents accept him (although they wish he was Jewish) and his mother really likes me.I rarely see other couples like us, though... usually it"s an Asian girl with a white guy. I"m wondering if there"s anyone else like me out there? Lethe [more]IP: Logged Posts: N/A Group: Guest Joined: Not Yet Status:| Hey Luv2Me,There are other white female/Asian male couples, though I agree, I don"t see many wandering the streets, either. I"m pretty sure there are several on here...My fiance is Korean-American, and I"m a Dutch/German -descended Midwestern girl. I"m not entirely clear on why the disparity between AF/WM couples and WF/AM couples exists, though I"ve heard a lot of theories about it, ranging from the reasonable to the insane - someone once warned me in all seriousness that Asian men"s penises were too small to satisfy a white woman (and NO this isn"t true, duh). I"ve also been warned that they were all inherently sexist (also untrue). But then again, with these kinds of stupid questions wandering around, no wonder... --Lethe. shanshiyi more]IP: Logged Posts: N/A Group: Guest Joined: Not Yet Status:| I understand that situation you mentioned coz white girls are usually slightly bigger and taller than some Asian guys so it doesn"t look compatible to each other. ANd usually bigger girls want to date guys who are bigger or taller than them.But In Hong Kong, I witness many White girls date Chinese -look guys as many as White guys date Chinese -look girls. Chinese guys in university- days are still slim but they will become physicially bigger after 24 or 25. They can be compatible to white girls then.P.S. My male friends go to high school in the US and they all did once and some still are dating White girl-clasmates. Probably teenager girls do not care about body size.
2023-06-25 03:57:471

Mc Jin 中文字幕

shooter.cn
2023-06-25 03:57:575

欧阳靖rap

[1]JIN: jin vs hasan with a name like "hasan" you should join the talaban cause that"s the only way you"ll get flex to drop a bomb when they retire me and i land in the booth. you"ll be outside tryin to shake hands with scoop. you got six victories?i wonder if this will hurt the closest you"ll get to 7 is the numba on ya shirt yeah im chinese now you understand it .im the reason that his little sister"s eyes is slanted if you make one joke about rice or karate nypd be in chinatown searchin for your body ask free she"ll tell you to duck down he thought the harlem shake was a drink from uptown whacha want to do son? i"m ill when i spit i"m tellin you right now yo, you aint legit cause when i finish spittin 看到你那"hasan"的名字,我觉得你该加入塔利班 如此一来你就能名正言顺的制造爆炸事件了 当我退休开小摊儿的时候 没准你正在街上对狗骑兔子招手(搭便车)呢 你卫冕六周吗?告诉你个不幸的消息 你卫冕-TSHIRT上的数字顶头也就是七了 没错 我是中国人,现在你明白了吧? 是我把你妹震得嘴歪眼斜的 你小子要是敢拿大米和空手道开一个字的玩笑 横尸唐人街就是你的下场 顺便说一句,她会让你卧倒 黑人区的街头生活可不象上流社会那么悠闲 怎么着吧孙子?你丫想干吗?我不爽就要骂! 听好了!我不骂爽了还不算完! [2]JIN: jin vs sterling (notorious big - one more chance) you wanna say im" chinese sonny? here"s a reminder check your tims they probably say "made in china" don"t make me get on this tip and straight kill ya his name is sterling cause all he rocks is silver dude, you, stop followin trends your girl must love alcohol cause she be swallowin" jin yo imma bout to flip the when it"s comin" to it aye yo you see me spittin on the block you runnin to it this is 106 and park, i"m a hard act to follow you a amateur, you go to the apollo cause i"m freestyling know when i"m done son, you ain"t a baller tell the audience the truth i saw him breakdancing for spare change on 40-deuce 宝贝儿!你想取笑我是中国人,给你提个醒. 你那靴子上写着"中国制造"呐 让我一下抓住你这个错把你说得无语 你那亮闪闪的银链子比你名字拉风多了 我说哥们,别见样学样 你的妞肯定喝高了,因为她正suckin jin"s dick(就不写中文了,大伙都明白.呵呵) 我走哪你跟哪 我吐口痰你都狠不得过去舔两口 这是在106 and park,想学我可不容易 你要是个业余的就去apollo吧 我正freestyle呢,孙子,好好听着就快完了 跟观众说实话吧,你屁也不是 我看见这孙子刚才跳霹雳舞了! [3]JIN: jin vs skitzo (busta rhymes f/ p. diddy - pass the courvoisier pt ii) yo, you a sucka and i mean it kid my girl would never go with you cause she don"t like guys with small penises don"t make me have to come at you aye yo, cause as a rapper, you really don"t have a chance better off asking nelson to teach you how to dance my freestyle is about to tear you up i"m really somethin that you not use to he at first wanna open a fortune sayin you"re a loser four more weeks i"m in the hall of fame with posterboy then you can join my street team and put up posters, boy you ain"t close to me my manager"s about to get me a deal his manager"s baggin groceries claim you clap guns supersoakers make noise he the type to play strip poker with his boys 你小子是个彻头彻尾的王八蛋 我的妞永远不会找你因为你的老二尺寸太小 别逼我打你 因为我是个RAPPA,你根本没机会 还不如找nelson让他教你怎么跳舞呢 我的FREESTYLE能把你损个底儿掉 我的水平你望尘莫及 他想在开场给我难堪,结果事与愿违 再有四周我就功成名就了,小子 到时候你可以进我的队里还能沾光上海报呢,小子 你跟我没法比,我的经纪人给我签了份合同 你的呢?沿街要饭呢吧? 给丫鼓倒掌!把他嘘下台! 他也就有跟他那帮小子玩剥猪猡的能耐 [4]JIN: jin vs. logan yo, if the rap game is whack everybody"s blamin you you from brookyln? then biggie mush be ashamed of you cause imma freestyle, show you how it is matter fact, you from bk, i heard they murder things only time he see beef is when he go to burger king i"m the player in the game you cheerin in the stands matter fact, durin the superbowl, he was cheerin for the rams you don"t even like football that"s a myth like unicorns he just like seein" grown men in tight uniforms i"m freesylin when im kickin it so ridiculous, put yourself in a bad predicament by the way, my little sister has somethin to say "there"s no way you"ll beat my brother on freestyle friday!" 如果这场你输了,大伙会骂死你 你从布鲁克林来的?biggie将以你为耻 我正在FREESTYLE,让我教教你怎么做吧 你真从布鲁克林来吗?事实上,我听说过一条爆炸性新闻 他每次去”汉堡王”时,才能尝一次荤 舞台上我是老大,你只能站那给我叫好 事实上,”超级碗”杯上,他是给公羊队叫好的 你说喜欢橄榄球,真是无稽之谈,扯淡 你只不过想看看那些穿着紧身队服的壮男 当我正在FREESTYLE时发现你的RAP把你自己置于一个尴尬境地,太滑稽了 稍等,我的小妹妹有话说 ”想在freestyle friday上赢我哥哥,没门!” [5]JIN: jin vs. luck luciano uh, see, i really don"t know what you"re doin he got a kobe bryant jersey on but look more like a light-skin patrick ewing i"m nice wit it when im spittin come on, in a week or so i"ll be spittin onzz beatz while you"ll be at the bodega askin forss cheese im nice with it freestyle come on you wanna talk about guns that"s why you get your studder on only toast he packs is the kind you put butter on i"m nice with it when i free come on, yo check it out, ask your girl i was doin somethin at her house matter fact, she had my eggroll and my dumplings in her mouth next time you see her bring extra protection next time you see her it"s a rap 真不知道你想干吗?不伦不类 穿着科比的运动衫看着却像个稍微白点的帕特里克.由因 我RAP的时候很酷 再过一两周我就我的身份就更不同了 而你呢?在饭馆讨食吃吧! 我FREESTYLE时更酷 你想谈谈枪火?先把扣子系好吧. 你吃烤面包时也就抹点黄油罢了(可能是损他肚子里没词吧) 我FREESTYLE时感觉棒极了 问问你的马子在屋里和我干过什么? 事实上,她把我的蛋蛋和JIJI放在了她嘴里 下次带她出来时多加小心 下次你看见她 这是RAP????(这句莫名其妙) [6]JIN: jin vs. skazoo yo, i get girls who you tryin to dis man? he masturbate so much he had to roc a wristband you got guns pointed my way he"s so played out i thought he was the old school joint of the day i got fans across the country jin is who they feelin" last time he had a fan it was spinnin on the ceilin" i go online, and check my hotmail he go on the internet lookin for hot males you aint a hustler your man"s coppin the work he be at the club, like tweet, droppin his skirt oops, i didn"t know my freestyle teared up you up on stage but it"s a pity though don"t make me spit in your mouth like missy"s old video im nice with it 我马子成堆,你想损谁啊? 他手淫过多,袖口都脏了. 你想打败我?别费劲了, 你就是个唱OLD SCHOOL的最傻的傻大个 我的粉丝遍布全国. 你最近的一个粉丝现在再天花板上吊着呢 我上网是为了查邮件 他上网是为了找GAY 你不是拉皮条的 你的同志们再夜总会工作, 看起来就像TWEET脱裙子一样滑稽(tweet好象是那个坐椅子上的胖子) 哦!不好意思,我什么也没说,我让你再台上一败涂地 尽管你很不幸,但也别惹我,当心我像MISSY当年的MV一样吐痰在你嘴里 [7]JIN: jin vs. sean nicholas you aint a regee arist and i aint hatin on you stop lyin mrs. cleo is more jamaican than you i"m nice with it when i"m freein who you think you bein"? my pants are new my sweater is new don"t be mad at chinese kid dressed better than you man im freestylin" now its a rap, matter fact you should ask clef... how to make your flow tighter better yet, pay him 20 g"s to be your ghostwriter i"m nice when i"m freein" you ain"t beatin me matter fact i"ll be a buffet and you ain"t eatin me and don"t make me start rappin in chinese on the microphone "nei fan oak kay lah" that means take your sorry butt home! 你要不唱雷鬼我还不想骂你 别扯淡了,mrs. cleo 比你更像牙买加人 我现在骂你骂的很爽,你以为你是谁? 我的裤子是新的,运动衫也是新的 别一看中国人穿的比你好就急眼 你知道什么是RAP什么是FREESTYLE吗? 你该请教clef怎么把你的FLOW控制好 然后给他20块让他为你捉刀写词 你想打败我,别做梦了 其实你根本不是我对手 别让我用中文骂你 nei fan oak kay lah 就是说”抬起屁股滚蛋!!” ***饶舌擂台赛现场经典对战*** 你以为你是谁?李小龙? 穿着条向下掉的裤……我到这里来不可以不让我讲粗口,来肯定我是社会地位低下的黑人,我永远不会冷静下来,这是对的,因为你好像一个纸老虎,我想在你的尾巴上咬一口……喂!我没昏头……根本就不会说饶舌,还来凑热闹,饶舌不是你们中国人可以学得会的! 你不是雷鬼音乐表演家,而且我不恨你,不要讲大话啦,你是牙买加人你比我更清楚……你不能再这样愚蠢,不要跟个比你穿得好的中国人发疯……去问你老师怎么才能把裤子穿好,或者给他20块钱让他帮你写歌词……我即兴说唱时我是好人……不要让我开始用中文在麦克前骂你……要你带着遗憾回家啦!
2023-06-25 03:58:371

写出同类单词附中文: I‘m hungry . I want some cakes, ( ) ( ) ( ) and ( )

你好!dildosandvaginas。我想要一些蛋糕,番茄和糕点.Iwantsomecakes;mhungry,penises,chicks,鸡肉,土司I".我饿了如有疑问,请追问。
2023-06-25 03:58:452

这是什么?

这是一段无聊的,聊天记录。
2023-06-25 03:59:071

写出同类单词附中文: I‘m hungry . I want some cakes, ( ) ( ) ( ) and ( )

I"m hungry. I want some cakes, chicks, penises, dildos and vaginas.我饿了。我想要一些蛋糕,鸡肉,土司,番茄和糕点。
2023-06-25 03:59:152

How many penises do you have?

翻译吗?请问你有多少便士?
2023-06-25 03:59:221

who is better ,man or woman

why it"s better to be a woman Several months ago, my friend Chip wrote an essay entitled, Why It"s Better to Be a Man. While it included a few convincing arguments (men don"t have to carry purses; men have less to shave), I was disappointed he could only come up with 10 reasons. After all the time I"ve spent listening to men rave about their units — not to mention enduring the phallic homages played out in skyscrapers, modern art and heavy metal — you would think there would be more than 10 lousy reasons. I can think of 10 reasons not to long for what the boys got:1. Women Get to Wait in Line at Public RestroomsThis might seem like an argument for the opposite camp, but think of the times you"ve been at a baseball game or monster truck pull having a perfectly miserable time with a male companion. By excusing yourself to stand on line at the biffy, you were reunited with many of your own gender, and as you inched forward, flush after flush, you began to talk — really talk — with these women (shared discomfort creates deep trust and mutual understanding). By the time you made it to the stall you were hugging your companions goodbye and exchanging phone numbers — friends for life! Men, on the other hand, are in and out of the head in no time. Do you think it"s a coincidence that men have difficulty creating close and lasting friendships with other men?2. Women Get a DoorThis is related to reason one. There"s something unseemly about having to pull out your goods for public display, and ... horrors, I can"t even go on!3. Women Get to Sit DownThere"s been some controversy on this topic, thanks to Camille Paglia, who writes in her book Sexual Personae: "Male urination is a kind of accomplishment, an arch of transcendence. A woman merely waters the ground she stands on." I can"t speak for Camille, but only in extreme cases of toilet deprivation have I ever "watered the ground I stood on." I prefer to sit.4. Men Make More MoneyMen, propelled by their willies and some prehistoric hunt-and-gather mindset, spend their nasty lives clawing, sniping and scratching their way to the top of the pay scale, all the while eating fatty foods, losing their hair and clogging their arteries, until one day — kablooey! — they keel over. When they"re gone, it"s the women (who live longer) who spend what"s left. All those old ladies you see at the travel agency collecting stacks of cruise brochures are having fun, fun, fun!5. Women Never Worry About Whose is BiggerNo matter what we tell men about how much size doesn"t matter, it does. (Well, it doesn"t really, but we talk about it with our girlfriends, anyway.) Knowing this, women can feel fortunate that we don"t attach much of our identity to something we can only see in a hand-held mirror.6. Women Are Better LookingBecause women don"t have penises, and therefore, loads of violence-inducing testosterone coursing through our veins, we"re prettier, softer, have less stubbly black hair, smell better, and are basically more lovely to behold. When men can"t understand why we spend so much time in the bathroom, it"s because they don"t know the joy of appreciating one"s lovely mug in the mirror.7. Women Have BreastsGiven the preoccupation that straight men have with these, it puzzles me that Freud never came up with a Breast Envy theory. Breasts are fun, no matter what shape, size or agenda, be it nutritional or recreational. They are soft, reassuring, and in their passive splendor, a far more potent sexual asset than any dangling penis.8. Women Have PeriodsAs a woman, I am allowed to eat copious amounts of food, yell at my loved ones, cry uncontrollably for no reason, and when it"s all over, say "I can"t help it. I"m having my period." When men behave this irrationally, which they are known to do, they have no excuse.9. Women Bear ChildrenMen and their equipment make an important contribution to the reproductive cycle, but their role is much like that of the center on a football team: He hikes the ball, she carries it for a touchdown. Being pregnant might be more of a burden if it weren"t for the fact that men suffer so much more seeing what their seed has done to the women they love. Labor pains are brief compared to the torment you can inflict on a man just by smiling weakly and saying, "That"s OK, honey. I"m sure you would have been glad to carry Junior, if only you could."10. Women Have a Hidden AgendaYou can"t play hard to get when your intentions are standing at attention. You know what I"m talking about — the pleading eyes, the heaving chest, the sudden alertness in his nether regions — it"s so obvious, for God"s sake. For women, it is a blessing to be able to withhold some cards from the sexual table, thus creating a sense of mystery and promise. Think of it as hiding one"s light under a bushel.
2023-06-25 03:59:311

欧阳靖美国说唱比赛的歌词!要英文的!对方的也要!

给你个网页 http://zhidao.baidu.com/linkurl=NEEA_CXo7X_seaAxShAHWzCXxFLHKhcV-Hk5zWkNsjos6SA3Di3lUgCS3SFlWF7w-7PsWMxWMfZBeClz0n6PLq
2023-06-25 04:00:012

《frendship》的英语作文

自己不会写啊,要别人写,这叫作弊,而且分都不给
2023-06-25 04:01:042

MC jin在freestyle Friday连胜7周德中文字幕

[1]JIN: jin vs hasan with a name like "hasan" you should join the talaban cause that"s the only way you"ll get flex to drop a bomb when they retire me and i land in the booth. you"ll be outside tryin to shake hands with scoop. you got six victories?i wonder if this will hurt the closest you"ll get to 7 is the numba on ya shirt yeah im chinese now you understand it .im the reason that his little sister"s eyes is slanted if you make one joke about rice or karate nypd be in chinatown searchin for your body ask free she"ll tell you to duck down he thought the harlem shake was a drink from uptown whacha want to do son? i"m ill when i spit i"m tellin you right now yo, you aint legit cause when i finish spittin 看到你那"hasan"的名字,我觉得你该加入塔利班 如此一来你就能名正言顺的制造爆炸事件了 当我退休开小摊儿的时候 没准你正在街上对狗骑兔子招手(搭便车)呢 你卫冕六周吗?告诉你个不幸的消息 你卫冕-TSHIRT上的数字顶头也就是七了 没错 我是中国人,现在你明白了吧? 是我把你妹震得嘴歪眼斜的 你小子要是敢拿大米和空手道开一个字的玩笑 横尸唐人街就是你的下场 顺便说一句,她会让你卧倒 黑人区的街头生活可不象上流社会那么悠闲 怎么着吧孙子?你丫想干吗?我不爽就要骂! 听好了!我不骂爽了还不算完! [2]JIN: jin vs sterling (notorious big - one more chance) you wanna say im" chinese sonny? here"s a reminder check your tims they probably say "made in china" don"t make me get on this tip and straight kill ya his name is sterling cause all he rocks is silver dude, you, stop followin trends your girl must love alcohol cause she be swallowin" jin yo imma bout to flip the when it"s comin" to it aye yo you see me spittin on the block you runnin to it this is 106 and park, i"m a hard act to follow you a amateur, you go to the apollo cause i"m freestyling know when i"m done son, you ain"t a baller tell the audience the truth i saw him breakdancing for spare change on 40-deuce 宝贝儿!你想取笑我是中国人,给你提个醒. 你那靴子上写着"中国制造"呐 让我一下抓住你这个错把你说得无语 你那亮闪闪的银链子比你名字拉风多了 我说哥们,别见样学样 你的妞肯定喝高了,因为她正suckin jin"s dick(就不写中文了,大伙都明白.呵呵) 我走哪你跟哪 我吐口痰你都狠不得过去舔两口 这是在106 and park,想学我可不容易 你要是个业余的就去apollo吧 我正freestyle呢,孙子,好好听着就快完了 跟观众说实话吧,你屁也不是 我看见这孙子刚才跳霹雳舞了! [3]JIN: jin vs skitzo (busta rhymes f/ p. diddy - pass the courvoisier pt ii) yo, you a sucka and i mean it kid my girl would never go with you cause she don"t like guys with small penises don"t make me have to come at you aye yo, cause as a rapper, you really don"t have a chance better off asking nelson to teach you how to dance my freestyle is about to tear you up i"m really somethin that you not use to he at first wanna open a fortune sayin you"re a loser four more weeks i"m in the hall of fame with posterboy then you can join my street team and put up posters, boy you ain"t close to me my manager"s about to get me a deal his manager"s baggin groceries claim you clap guns supersoakers make noise he the type to play strip poker with his boys 你小子是个彻头彻尾的王八蛋 我的妞永远不会找你因为你的老二尺寸太小 别逼我打你 因为我是个RAPPA,你根本没机会 还不如找nelson让他教你怎么跳舞呢 我的FREESTYLE能把你损个底儿掉 我的水平你望尘莫及 他想在开场给我难堪,结果事与愿违 再有四周我就功成名就了,小子 到时候你可以进我的队里还能沾光上海报呢,小子 你跟我没法比,我的经纪人给我签了份合同 你的呢?沿街要饭呢吧? 给丫鼓倒掌!把他嘘下台! 他也就有跟他那帮小子玩剥猪猡的能耐 [4]JIN: jin vs. logan yo, if the rap game is whack everybody"s blamin you you from brookyln? then biggie mush be ashamed of you cause imma freestyle, show you how it is matter fact, you from bk, i heard they murder things only time he see beef is when he go to burger king i"m the player in the game you cheerin in the stands matter fact, durin the superbowl, he was cheerin for the rams you don"t even like football that"s a myth like unicorns he just like seein" grown men in tight uniforms i"m freesylin when im kickin it so ridiculous, put yourself in a bad predicament by the way, my little sister has somethin to say "there"s no way you"ll beat my brother on freestyle friday!" 如果这场你输了,大伙会骂死你 你从布鲁克林来的?biggie将以你为耻 我正在FREESTYLE,让我教教你怎么做吧 你真从布鲁克林来吗?事实上,我听说过一条爆炸性新闻 他每次去”汉堡王”时,才能尝一次荤 舞台上我是老大,你只能站那给我叫好 事实上,”超级碗”杯上,他是给公羊队叫好的 你说喜欢橄榄球,真是无稽之谈,扯淡 你只不过想看看那些穿着紧身队服的壮男 当我正在FREESTYLE时发现你的RAP把你自己置于一个尴尬境地,太滑稽了 稍等,我的小妹妹有话说 ”想在freestyle friday上赢我哥哥,没门!” [5]JIN: jin vs. luck luciano uh, see, i really don"t know what you"re doin he got a kobe bryant jersey on but look more like a light-skin patrick ewing i"m nice wit it when im spittin come on, in a week or so i"ll be spittin onzz beatz while you"ll be at the bodega askin forss cheese im nice with it freestyle come on you wanna talk about guns that"s why you get your studder on only toast he packs is the kind you put butter on i"m nice with it when i free come on, yo check it out, ask your girl i was doin somethin at her house matter fact, she had my eggroll and my dumplings in her mouth next time you see her bring extra protection next time you see her it"s a rap 真不知道你想干吗?不伦不类 穿着科比的运动衫看着却像个稍微白点的帕特里克.由因 我RAP的时候很酷 再过一两周我就我的身份就更不同了 而你呢?在饭馆讨食吃吧! 我FREESTYLE时更酷 你想谈谈枪火?先把扣子系好吧. 你吃烤面包时也就抹点黄油罢了(可能是损他肚子里没词吧) 我FREESTYLE时感觉棒极了 问问你的马子在屋里和我干过什么? 事实上,她把我的蛋蛋和JIJI放在了她嘴里 下次带她出来时多加小心 下次你看见她 这是RAP????(这句莫名其妙) [6]JIN: jin vs. skazoo yo, i get girls who you tryin to dis man? he masturbate so much he had to roc a wristband you got guns pointed my way he"s so played out i thought he was the old school joint of the day i got fans across the country jin is who they feelin" last time he had a fan it was spinnin on the ceilin" i go online, and check my hotmail he go on the internet lookin for hot males you aint a hustler your man"s coppin the work he be at the club, like tweet, droppin his skirt oops, i didn"t know my freestyle teared up you up on stage but it"s a pity though don"t make me spit in your mouth like missy"s old video im nice with it 我马子成堆,你想损谁啊? 他手淫过多,袖口都脏了. 你想打败我?别费劲了, 你就是个唱OLD SCHOOL的最傻的傻大个 我的粉丝遍布全国. 你最近的一个粉丝现在再天花板上吊着呢 我上网是为了查邮件 他上网是为了找GAY 你不是拉皮条的 你的同志们在夜总会工作, 看起来就像TWEET脱裙子一样滑稽(tweet好象是那个坐椅子上的胖子) 哦!不好意思,我什么也没说,我让你在台上一败涂地 尽管你很不幸,但也别惹我,当心我像MISSY当年的MV一样吐痰在你嘴里 [7]JIN: jin vs. sean nicholas you aint a regee arist and i aint hatin on you stop lyin mrs. cleo is more jamaican than you i"m nice with it when i"m freein who you think you bein"? my pants are new my sweater is new don"t be mad at chinese kid dressed better than you man im freestylin" now its a rap, matter fact you should ask clef... how to make your flow tighter better yet, pay him 20 g"s to be your ghostwriter i"m nice when i"m freein" you ain"t beatin me matter fact i"ll be a buffet and you ain"t eatin me and don"t make me start rappin in chinese on the microphone "nei fan oak kay lah" that means take your sorry butt home! 你要不唱雷鬼我还不想骂你 别扯淡了,mrs. cleo 比你更像牙买加人 我现在骂你骂的很爽,你以为你是谁? 我的裤子是新的,运动衫也是新的 别一看中国人穿的比你好就急眼 你知道什么是RAP什么是FREESTYLE吗? 你该请教clef怎么把你的FLOW控制好 然后给他20块让他为你捉刀写词 你想打败我,别做梦了 其实你根本不是我对手 别让我用中文骂你 nei fan oak kay lah 就是说”抬起屁股滚蛋!!” ***饶舌擂台赛现场经典对战*** 你以为你是谁?李小龙? 穿着条向下掉的裤……我到这里来不可以不让我讲粗口,来肯定我是社会地位低下的黑人,我永远不会冷静下来,这是对的,因为你好像一个纸老虎,我想在你的尾巴上咬一口……喂!我没昏头……根本就不会说饶舌,还来凑热闹,饶舌不是你们中国人可以学得会的! 你不是雷鬼音乐表演家,而且我不恨你,不要讲大话啦,你是牙买加人你比我更清楚……你不能再这样愚蠢,不要跟个比你穿得好的中国人发疯……去问你老师怎么才能把裤子穿好,或者给他20块钱让他帮你写歌词……我即兴说唱时我是好人……不要让我开始用中文在麦克前骂你……要你带着遗憾回家啦!
2023-06-25 04:01:121

谁会唱rap滴教下5~

你试下听 lose yourself
2023-06-25 04:01:193

penis of a bull什么意思

penis of a bull公牛的阴茎penis英 [ˈpi:nɪs] 美 [ˈpinɪs]n.阴茎,阳物阴茎;阳茎;阳物;男性生殖器复数: penisesbull英 [bʊl] 美 [bʊl]n.公牛; 股市看涨的人; 力大如牛的人; 大型雄性动物vt.[证券]从事投机使(证券等)价格上涨; 推,强迫; 强力实现; 对…施加压力,强使…通过vi.[证券](证券、股票等)价格上涨; 哄抬证券价格; 走运,提高身价; 猛推,猛挤,猛力向前adj.公的,雄的; 力大如牛的; 价格上涨的芝加哥公牛;公牛;废话;多头复数: bulls 过去式: bulled 过去分词: bulled 现在分词: bulling 第三人称单数: bulls
2023-06-25 04:01:261

请问去香港那个里有唱片买?最好是在尖沙咀附近!

去海港城吧,那里位於 香港 九龙 尖沙咀 ,是香港最大面积的购物中心及名牌集中地,那里有一家唱片叫:香港唱片 详情:香港唱片地区:海港城.港威商场楼层:3商店号码:3320电话号码:2175 5700 2175 5766营业时间:10:00 AM - 10:00 PM
2023-06-25 03:58:312

弗洛伊德人格理论的人格发展理论有哪些阶段?

(1)口腔期(the oral stage,0~1 岁),性本能通过口腔活动得到满足,如咀嚼、吸吮或咬东西。若母亲对婴儿的口腔活动不加限制,儿童长大后的性格将倾向于开放、慷慨及乐观;若其口腔需要受到挫折,则未来性格发展可能偏向悲观、依赖和退缩。可见,弗洛伊德认为早期的经验对人格的发展会有长期的影响。(2)肛门期(the anal stage,1~3岁),随着括约肌的逐渐成熟,婴儿获得了依照自己的意愿大小便的能力。按自己的意志大小便是满足婴儿性本能的最主要的方式。但这一时期也正是成人对婴儿进行大小便训练的时期,要求婴儿在找到适当的场所之前必须忍住排泄的欲望,这与婴儿的本能产生了冲突。弗洛伊德认为母亲在训练婴儿大小便时的情绪气氛对其未来人格发展影响重大。过分严格的训练可能会形成顽固、吝啬的性格;而过于宽松又可能形成浪费的习性。 (3)性器期(the phallic stage,3~6岁),这一时期的儿童开始对自己的性器官产生兴趣,性器官成为全身最敏感的部位,儿童常以抚摸性器官获得快感。弗洛伊德认为这一时期的儿童都会产生想与异性父母有性爱关系的欲望,即所谓恋母情结或恋父情结。在正常发展的情况下,恋母情结或恋父情结会通过儿童对同性父母的认同,吸取他们的行为、态度和特质进而发展出相应的性别角色而获得解决。 (4)潜伏期(the latency stage,6~11岁),这个阶段,儿童的性本能是相当安静的,有关性的和侵犯的幻想大部分都潜伏起来,埋藏在无意识当中。性器期时性的创伤已被遗忘,一切危险的冲动和幻想都潜伏起来,儿童不再受到它们的干扰。儿童可以自由地将能量消耗在为社会所接受的具体活动当中去,如运动、游戏和智力活动等。 (5)两性期(the genital stage,也称青春期),一般女孩于11岁开始,男孩于13岁开始。随着生殖系统逐渐成熟,性荷尔蒙分泌的增多,性本能复苏,其目的是经由两性关系实现生育。这一时期的心理能量主要投注在形成友谊、生涯准备、示爱及结婚等活动中,以完成生儿育女的终极目标,使成熟的性本能得到满足。
2023-06-25 03:58:322

窄而浅配置策略有哪些连锁店

窄而浅配置策略的连锁店有HMV、GameStop、Bath&BodyWorks。1、HMV:这是一家以售卖音乐和影视制品为主的连锁店,集中经营某个领域的少数种类产品。HMV在全球范围内拥有超过400家门店,是音乐和影视制品零售业中的知名品牌之一。2、GameStop:这是一家以售卖电子游戏和游戏机为主的连锁店,也是采用“窄而浅”策略的典型代表之一。GameStop在全球范围内拥有超过5000家门店,是电子游戏零售业中的领先品牌之一。3、Bath&BodyWorks:这是一家以售卖沐浴用品、护肤品和香氛产品为主的连锁店,同样采用“窄而浅”策略。Bath&BodyWorks在美国拥有超过1700家门店,是沐浴用品和护肤品零售业中的领先品牌之一。
2023-06-25 03:58:381

在香港hmv网购需要收关税吗?

不需要关税,邮费那么贵吗?以前从香港邮寄东西,才几十元的,不知道音像制品是不是有特殊要求!最好是问问客服,给他们发邮件确认一下,广东那么近!
2023-06-25 03:58:451

龟头周围有很多小肉芽是病吗

龟头流脓常见于淋球菌性尿道炎,淋球菌性尿道炎是很常见的,一种性传播疾病,淋球菌是一种革兰阴性双球菌,人类是其唯一的速度,链球菌感染人体后主要寄生在尿道粘膜引起排尿时尿道刺痛,并且尿道脓性分泌物增多
2023-06-25 03:58:4810

在香港HMV看到一个牛皮纸盒包装的黑色头戴式耳机,品牌和logo是M开头的,求问耳机的品牌

魔声,monster?
2023-06-25 03:58:534

HMV—5净水器,净化出来的水烧开后有水垢有异味,还能直接食用吗?怎么处理

? 前八十回
2023-06-25 03:59:037

5sMA350后级功放是国产的吗?

功放也就是我们说的“扩音机”,它主要作用就是将音源放大器的弱信号放大,是音响系统中最基本的设备。一套优秀的音响系统,功放的作用功不可没。市面上的功放品种众多,其中纯后级功放也深受消费者的喜爱。纯后级功放如何选择1、印刷的字体纯后级功放的正品字体匀称清秀,而假品的字体用手指甲轻轻一刮,字迹颜色变浅、甚至容易掉漆看不清。2、看品牌还要注意选购纯后级功放的品牌,比如说Chord 和弦、Linn 莲、Primare 翩美、T+A 德国、OCTAVE/八度、EINSTEIN 爱因斯坦、Audionet 德国、Brinkmann贝金曼都是不错的品牌,可以放心选购。2、听效果纯后级功放的音效非常重要,最直接的方式就是听一下音效,如今网购越来越方便,很多人都不愿意去实体店购,其实对于音响装备来说,还是实体去体验最好。每个人对于音质的追求都是不一样的。3、看性能先查看一下纯后级功放信号处理、功率输出及驱动性能效果如何,建议对照具体的产品数据进行参考。
2023-06-25 03:59:072

男人的染色体是46xx表示什么?

不会是变异了吧!
2023-06-25 03:59:127

innocent什么意思

innocentadj. 无辜的;无罪的;无知的n. 天真的人;笨蛋n. (Innocent)人名;(英、西)因诺森特;(法)伊诺桑比较级 more innocent最高级 most innocent复数 innocents
2023-06-25 03:59:131

就是我买的AKB48神曲 我的那个是特典的与通常盘有区别么

没,就是长的不同
2023-06-25 03:59:182

innocent名词

innocent的名词形式是innocent。nnocent是一个英语单词,名词、形容词,作名词时意思是“天真的人;笨蛋”,作形容词时意思是“无辜的,无罪的,无知的”。单词发音 英[??n?snt],美[??n?snt]短语搭配 Presumed Innocent无罪的罪人。
2023-06-25 03:59:261

四肢换季会出现疱疹型红色很痒跟性病有关系吗

疱疹包括:1.单纯疱疹2.带状疱疹3.生殖器疱疹,其中3归到性传播疾病中。单纯疱疹是一种由人类单纯疱疹病毒(HSV)感染所引起的病毒性皮肤病。传染性很小。带状疱疹系由水痘-带状疱疹病毒引起,初次感染水痘-带状疱疹病毒后表现为水痘或呈隐性感染,以后病毒长期潜伏于脊髓后根神经节的神经元内,当机体抵抗力下降及各种诱发刺激的作用下,可使之再活动,生长繁殖,引起相应神经分布区的水疱疹和神经痛,即带状疱疹。传染性较小,小儿易患水痘。生殖器疱疹(herpesgenital)是由单纯疱疹Ⅱ型病毒通过接触而传染的疾病。此病当机体抵抗力下降,如发热、劳累等因素下,易于发生。表现为群集丘疱疹,水疱、糜烂、灼热感。传染性较大
2023-06-25 03:58:241

900-1300HmV是HRC多少硬度

理论上如果定罪了会直接转入监狱而不是看守所服刑,一般只有还未定罪的的才会羁押在看守所,这个只有等法院判决书下来,如果是最轻的,一般也就是三年以上,换句话说,判决下达之日减去你朋友在看守所羁押的时间,很快就可以出来了
2023-06-25 03:58:243

弗洛伊德人格发展理论简述

一直想着怎样来写这最后两个阶段呢?从6岁开始的孩子已经进入了学校这个大社会,已经能有较为清晰的记忆,大人们也能回忆起自己的孩童阶段。同时,弗洛伊德的人格发展理论主要侧重在前面的三个阶段,武志红老师的讲解也是一带而过。先一起回顾下弗洛伊德的人格发展理论吧! 一、口腔期(oral stage,0~1岁) 吸允需求就是口腔期(也称口欲期)的重要表现。原始欲力的满足,主要靠口腔部位的吸允、咀嚼、吞咽等活动获得满足。快感中心在口腔部位,这一阶段需要发展出基本信任,也就是一个人由衷地相信,外部世界是愿意满足他,让他吸收养分的。此时期的口腔活动若受限制,可能会留下后遗性的不良影响。成人中有所谓的口腔性格,可能就是口腔期发展不顺利所致。在行为上表现贪吃、酗酒、吸烟、咬指甲等,甚至在性格上悲观、依赖、洁癖者,都被认为是口腔性格的特征。 二、肛门期(anal stage,1~3岁) 快感中心在肛门部位,这一阶段需要发展出基本自主感,孩子发现他可以基本按照自己意愿,去控制大便,这是孩子的第一个创造物,也将影响他对自己以后各种创造物的态度,其实也是一个人对金钱的态度。此时期卫生习惯的训练,对幼儿言是重要关键。如管制过严,可能会留下后遗性的不良影响。成人中有所谓的肛门性格者,在行为上表现冷酷、顽固、刚复、吝啬等,可能就是肛门性格的特征。 三、性器期(phallic stage,3~6岁) 原始欲力的需求,主要靠性器官的部位获得满足。此时幼儿喜欢触摸自己的性器官,在性质上已算是“手淫”的开始。幼儿在此时期已能辨识男女性别,并以父母中之异性者为“性爱”的对象。于是出现了男童以父亲为竞争对手而爱母亲的现象,这现象称为恋母情结,同理女童以母亲为竞争对手而爱恋父亲的对象,则称为恋父情结。这一阶段孩子发展的是竞争性与合作精神,也是超我形成的关键时期。 四、潜伏期(latent stage,6岁至12岁左右) 开始变得对同性更感兴趣,这一阶段特别要学习的是和同性伙伴的合作关系。六岁以后的儿童,兴趣扩大,由对自己的身体和父母感情,转变到周围的事物,故而从原始的欲力来看,呈现出潜伏状态。 五、生殖期(genital stage,青春期以后) 青春期性能量和攻击能量都爆炸般呈现,青少年开始真实地学习,如何合理地展现自己的能量。此时期开始时间,男生约在13岁,女生约在12岁,此时期个体性器官成熟生理上与心理上所显示的特征,两性差异开始显著。自此以后,性的需求转向相似年龄的异性,开始有了两性生活的理想,有了婚姻家庭的意识,至此,性心理的发展以臻成熟。 在前三个阶段,父母给孩子给予更多的理解和保护就能很好的相处,而在进入潜伏期后,感觉就像进入了与孩子的游击战。开始斗智斗勇的阶段,武志红老师的建议是提供一个抱持性环境,这样成长起来的青少年能展现自己的力量,也能懂得尊重别人,能竞争,也能合作。
2023-06-25 03:58:171

关于日本HMV购物

上个星期用的招行的学生卡(visa的)在hmv订了碟,没什么问题的人路过~
2023-06-25 03:58:171

geomagneticfield的翻译是什么

geomagneticfield的意思是:[地物]地磁场,地球磁场。geomagneticfield的意思是:[地物]地磁场,地球磁场。geomagneticfield的网络解释是地磁场:地磁场(geomagneticfield)地球是一个巨大的磁体,它在空间产生的磁场即地磁场.卫星探测发现,地磁场被局限在地球周围有限的区域内,这个区域叫地磁层.地磁轴和地球自转轴不相重合,地磁南极在地理北极附近,地磁北极在地理南极附近。geomagneticfield的例句是Thegeomagneticfieldvariescontinuously.地磁场不断地发生变化。一、网络解释点此查看geomagneticfield的详细内容1.地磁场:地磁场(geomagneticfield)地球是一个巨大的磁体,它在空间产生的磁场即地磁场.卫星探测发现,地磁场被局限在地球周围有限的区域内,这个区域叫地磁层.地磁轴和地球自转轴不相重合,地磁南极在地理北极附近,地磁北极在地理南极附近.2.地球磁场:genitalgland生殖腺|geomagneticfield地球磁场|geometricattenuation几何衰减3.地球磁场地球磁_:■geomagneticdeepsounding地磁测深法GDS法|■geomagneticfield地球磁场地球磁_|■geomagnetism地磁地磁_二、例句Thegeomagneticfieldvariescontinuously.地磁场不断地发生变化。Coilsofwirewillproduceelectricitywhilemovingintheearth"smagneticfield.线圈在地磁场中移动会产生电流。geomagneticfield的相关临近词GE、Gebir点此查看更多关于geomagneticfield的详细信息
2023-06-25 03:58:081

推荐一些比较好听经典的JAZZ音乐 谢谢!!

Dave Koz(戴夫u2022考兹)和Warren Hill(华伦u2022希尔)的迷情萨克斯与小野丽莎的民谣爵士乐颇有情调
2023-06-25 03:58:027

谁给我改文章?给分的!!!

用了compare就不必要用rather 就如同用了but 就不再用though
2023-06-25 03:57:533

日本HMV是不是免费邮寄

那必然是不可能的- -+即使你跟日本菩普通卖家做生意也要买到一定价格人家才会给你免邮的啊……毕竟是国际啊又不是国内快递十几RMB就搞定了= =
2023-06-25 03:57:521

试述弗洛伊德的人格发展论及其对心理健康的启示

师大心理的么···
2023-06-25 03:57:502

akb48 新单曲 选哪家店好

hmv的较好 我一直都hmv买的 店特一直都不错
2023-06-25 03:57:453

我想问一下尖锐湿疣..只通过性传播吗...还有什么传播方式..

尖锐湿疣(Genital Warts,Condyloma acuminata,verruca acuminata),又称尖圭湿疣、生殖器疣(阴部疣)、性病疣。近年来由于性病的外延不断扩大,此病被公认为性传播疾病,也是现代社会最常见的性传播疾病之一。 尖锐湿疣是欧美国家最常见的性病之一,其发病率逐年上升,据不完全统计,近15年来,美国尖锐湿疣的发病数增加了5倍。尖锐湿疣在我国也是最主要的性病之一,有些地区发病数占全部性病病人的20%~31%,为第2位或第3位。我国南方比北方多见,好发年龄在16~35岁之间。尖锐湿疣的传染性很强,发病率较高,在国外仅次于非淋菌性尿道炎和淋病,占第三位。在国内因尚无有效条件检测非淋菌性尿道炎,所以它居淋病之后,占第二位,其年增长率超过100%,居各类性病之首。因此,有些单位在体检时发现20-30%的女性患有尖锐湿疣也就不奇怪了。此病可在几个月内自然消退,但也有少数病人的病变持续多年,经久不愈。因而要及早发现、及时彻底治疗。 尖锐湿疣是性传播疾病之一,但与淋病、梅毒的传染方式不同,除了性接触所致之外,还有30-40%系接触污染物所致。 病理学 [病原体] 本病的病原体是人类乳头瘤病毒(HPV)。属DNA病毒。人体皮肤及粘膜的复层鳞状上皮上HPV的唯—宿主,尚未在体外培养成功。病毒颗粒直径为50~55nm。这是非常小的,一般光学显微镜是不能看到的,只有借助电子显微镜才能看到。人类乳头瘤病毒的类型很多,近年来分子生物学技术研究发展迅速,证实人类乳头瘤病毒有60种以上的抗原型,即这一家族里有60多个相似而又不同的病毒(亚型),其中至少有10个类型与尖锐湿疣有关(如6,11,16,18及33型,最常见6、11型),而第11,16,18型,则是国外目前研究宫颈癌、外阴癌甚至阴茎癌的最热门的病毒因子,其长期感染与女性宫颈癌的发生有关。尖锐湿疣与寻常疣、扁平疣、丝状疣、掌跖疣等,同为感染人类乳头瘤病毒(HPV)引起。但不同类型的HPV能引起不同的疣。如Ⅰ型主要引起掌跖疣,Ⅱ型主要引起寻常疣,Ⅲ型主要引起扁平疣,而尖锐湿疣主要是由Ⅵ型、Ⅺ型病毒感染所引起。HPV在温暖潮湿的环境中特别易生存增殖,故男女两性的外生殖器是最易感染的部位。病毒可自身接种,因此发生于肛门等部位的损害常出现于两侧接触面。 HPV为乳多空病毒科A属成员,病毒颗粒直径50-55nm无被膜的正20面体构成的病毒壳体,具有7900碱基对的环状双链DNA组成,电镜下病毒颗粒的大小、形态与口多瘤病毒极为相似。乳头瘤病毒(PV)具有种属特异性,HPV尚未能在组织培养或实验动物模型中繁殖。 病毒的结构蛋白组成:85%的PV颗粒,经十二烷基硫酸钠聚丙烯酰胺凝胶电泳(SDS——PAGE)可确定病毒有主要衣壳蛋白、分子量为56.000;次要衣壳蛋白,分子量迁移于76.000处,发现4种细胞组蛋白与病毒DNA相关。 所有HPV病毒的基因组结构相似,根据在严格条件下进行DNA杂交的程序可确定病毒的型和亚型,不同的HPV型DNA与其他类型病毒DNA仅50%出现交叉杂交,迄今已发现60多种HPV类型,随着研究的深入,将会鉴定出更多HPV新的类型。 [发病机理] 尖锐湿疣的HPV感染通过性接触传播,接触部位的小创伤可促进感染,三种鳞状上皮(皮肤、粘膜、化生的)对HPV感染都敏感。每一型HPV与特殊的临床损害有关,且对皮肤或粘膜鳞状上皮各有其好发部位。当含有比较大量病毒颗粒的脱落表层细胞或角蛋白碎片进入易感上皮裂隙中时,感染就可能产生,它可因直接接触或少见的自动接种或经污染的内裤、浴盆、浴巾、便盆感染。 病毒感染人体后,可潜伏在基底角朊细胞间,在表皮细胞层复制,HPV侵入细胞核,引起细胞迅速分裂,同时伴随病毒颗粒的繁殖与播散,形成特征性的乳头瘤。晚期基因表达结构多肽,即出现结构蛋白装配颗粒,病毒主要集中在颗粒层中的细胞核内,在表皮的颗粒层出现凹空细胞增多,组织学上正常的上皮细胞也有HPV,治疗后残余的DNA常可导致疾病的复发。 HPV在皮肤上引起疣赘、在咽部、肛周、生殖器粘膜上形成增殖性病变,其病毒型为小型DNA病毒。感染HPV发生病变多数属于良性,能自行消退,但也有恶化病例。如肛周、生殖器粘膜上形成扁平上皮癌的报道。还有罕见的遗传性皮肤疾患、疣赘状表皮发育异常症(EV)续发的皮肤癌等,在癌细胞中检出HPV。 流行病学 [流行情况] 尖锐湿疣为人类乳头瘤病毒所引起。目前一致认为此病在增多,成为STDS中的最常见疾病,在年轻成人中患病率可达0.5%-1%。英国尖锐湿疣发病率从1970年的30/10万增到1988年的260/10万,几乎增加了8倍,美国此病发病率从1966年到1984年增加了6倍。和艾滋病相似,有症状的尖锐湿疣仅代表感染者的“冰山”之顶,所以如考虑亚临床感染在内,人类乳头瘤病毒感染可能是发病率占第一位的性病。此感染的传播方式包括直接与间接传播,但以性接触最为常见,而且越是近期损害越有传染性,一次性接触估计有50%被传染的可能性;其次为直接非性接触,如自体传染以及新生儿经产道受染;再其次为间接接触,通过污染传染、推测有可能,但因此病病毒尚不能培养,未能证实。 二、尖锐湿疣发生的危险因素 (一)性行为:性伴数及过早性交是造成发生HPV感染的因素。 (二)免疫抑制:HPV感染和与HPV有关的癌似乎是慢性免疫功能抑制的晚期并发症。肾异体移植者中患CA的危险性增加。 (三)HIV感染:HIV阳性发生HPV感染及HPV相关肿瘤的机率增加。 (四)年龄,妊娠:在妇科涂片中检测HPV高峰流行率的年龄为20-40岁,随着年龄增加,流行率稳步下降;妊娠期间的HPV检出率高,产后HPV检出率下降。 [传播途径] 它具有高度接触传染性。尖锐湿疣的潜伏期长短不一,一般为3周~8个月,平均为3个月。有的患者,半年前有不洁性交,出现尖锐湿疣后,十分困惑,当大夫询问病史时,往往否认,其实,病毒在局部潜伏可达8个月之久而不发病,当人体的抵抗力下降时,病毒大量繁殖,即可发病。虽然这些患者未发病,病毒潜伏于人体,它也有传染性,同样是传染源。 (1)直接性接触传染 这是主要的传播途径。据研究有2/3与尖锐湿疣患者有性接触的人可发生本病。病期平均在3个半月时传染性最强,故在性混乱者中最易感染本病。通常通过不洁性交,经受损的皮肤和粘膜感染。调查资料表明,尖锐疣湿就多发生于20-30岁的青年人,而这些病人中,多数有婚外不洁的性乱史。 (2)母婴传染 婴幼儿尖锐湿疣或喉乳头瘤病和儿童的尖锐湿疣,可能是分娩过程中胎儿经过感染HPV的产道或在出生后与母亲密切接触而感染的。 (3)间接物体传染 可通过日常生活用品如内裤、浴盆、浴巾传染。如果女性穿着尼龙内裤,又不注意清洁外阴,霉菌性阴道炎或滴虫性阴道炎便容易发生,或出现其他感染所致的白带增多等情况时,局部的浸渍、潮湿便为乳头瘤病毒的接种,滋生繁衍提供了有利条件。用污染的手搔抓阴部或使用污染的毛巾也会引起尖锐湿疣的传染。引起感染的原因还有不注意阴部卫生或在便前不注意洗手。人们都知道饭前便后要洗手,殊不知便前或接触外阴(如更换月经栓或卫生棉)前更应洗手,人们只怕以手接触外阴会沾污手而不知手也会沾污外阴。 免疫学 宿主对HPV感染引起的免疫应答,包括细胞免疫与体液免疫两个方面。 一、细胞免疫 人体细胞免疫状态是影响CA发生、转归的重要基础之一。细胞免疫比体液免疫更为重要。临床上伴细胞免疫缺陷的尖锐湿疣患者皮疹常持续不退,其外周血中抑制性T细胞数增多NK细胞功能低下,r-干扰素和白细胞介素2产生减少,而消退疣皮损中常常出现活化T细胞和NK细胞的浸润,部分角朊细胞HLA-DR阳性。 免疫抑制或免疫缺陷时,生殖器HPV感染和HPV相关疾病的发生率均增加。尖锐湿疣中辅助性T细胞耗竭,CD4/CD8比值倒置,其值<1。在CA病人的外周血中,发现抑制/细胞毒性T细胞百分率显著增高,辅助/诱导性T细胞的比值和辅助/抑制T细胞比值均降低。宫颈CA和宫颈上皮内瘤样病变(CIN)病损中朗格罕细胞明显减少。CA中NK细胞 产生r-干扰素和白介素-2减少。鲍温样丘疹病和肛门生殖器癌者中NK细胞对含有HPV-16的角朊细胞的溶解活性下降,可能是对疾病特异性靶细胞的识别缺陷所致,宫颈CA的角朊细胞不表达MHCⅡ型抗原(HLA-DR),无此抗原提呈功能可以破坏免疫监视作用。 二、体液免疫 目前血清学检测结果显示:①抗晚期蛋白抗体产生率为25%-65%,较抗早期蛋白抗体产生率高;②检测出的HPV抗体似有型特异性,无交叉反应;③抗HPV-16E7抗体与宫颈癌的存在有密切关系;④抗HPV-16E4抗体也是发生宫颈癌、复发或近期HPV感染的标志;⑤估计成人和儿童产生IgG抗体的阳性率相同,不同型别阳性率在10%-75%之间;⑥已证明HPV-16或18型肿瘤抗体阳性患者中,仅50%-70%可检出该抗体。 三、尖锐湿疣自然消退 对CA自然消退尚无系统评估,然而以安慰剂对照研究发现其自然消退率在0%,17%、18%和69%之间,CA消退或治愈后,仍有45%患者存在潜伏感染,其中67%患者复发。 临床表现 潜伏期3周到8个月,平均3个月,多见于性活跃的青、中年男女,发病高峰年龄为20-25岁,病程平均在3-5个月的男女患者,在性接触后不久即发病,而病程平均12个月的男性患者,其性接触者可不发病。多数患者一般无症状。损害大小及形状不等。可仅为数个,亦可为多数针头样大的损害:在阴肛部可长成大的肿瘤样物,有压迫感;有恶臭味;有时小的湿疣可出现阴部痛痒不适,病人可出现尿血和排尿困难;直肠内尖锐湿疣可发生疼痛、便血,而直肠内大的湿疣则可引起里急后重感。 男性患者好发于包皮系带、冠状沟、包皮、尿道、阴茎、肛门周围和阴囊。病初为淡红或污红色粟状大小赘生物,性质柔软,顶端稍尖,逐渐长大或增多。可发展成乳头状或囊状,基底稍宽或有带,表面有颗粒。在肛门部常增大,状如菜花,表面湿润或有出血,在颗粒间常积存有脓液,散发恶臭气味,搔抓后可继发感染。位于湿度较低干燥部位的生殖器疣,损害常小而呈扁平疣状。位于湿热湿润部位的疣常表现为丝状或乳头瘤状,易融合成大的团块。有严重肝病的患者湿疣可增大。妊娠可使湿疣复发或生长加快。 亚临床感染是指临床上肉眼不能辨认的病变,但用3%-5%醋酸液局部外涂或湿敷5-10分钟可在HPV感染区域发白,即所谓“醋酸白现象”。 HPV感染和肿瘤的发生: (一)HPV与皮肤肿瘤的发生有关 它在皮肤癌和其他解剖部位的肿瘤似乎起决定作用。口腔良性赘生物和癌前病变,皮肤鳞状细胞癌组织中可发现HPV-11、16、18型DNA,曾报道喉部HPV-6乳头瘤恶变成喉癌,皮肤疣状表皮发育不良(EV)是HPV潜在致癌作用的证据,EV皮损中发现多种HPV型DNA,并在患者皮肤鳞状细胞癌中检出HPV-5、8、14、17及20型,皮肤鳞状细胞癌似乎是由先已存在的病毒性损害恶变而来。 (二)尖锐湿疣与肛门生殖器癌 生殖器癌与HPV类型有一定的关系。利用DNA杂交技术发现生殖器癌组织中存在HPV-6、11、16、18型等。 1.宫颈癌:根据HPV与宫颈癌的关系,可将其分为两大类型:低危型主要指HPV-6、11型,高危型是指HPV-16、18型,Gissmann等观察到在侵袭性宫颈癌中,有57.4%患者存在着HPV-16、18型,其他学者也有相同发现。还有人从侵袭性宫颈癌中分离出HPV-33和35型。 2.皮肤鳞状细胞癌(SCC):HPV感染而发生的CA也可能是癌前损害,并可发展成肛门生殖器SCC,这表明HPV是女阴、阴茎及肛门生殖器SCC的重要因素。CA,巨大CA和疣状SCC组成一个生殖器癌前病变和癌的损害病谱,有些部位生殖器癌病例在其周围皮肤有CA存在,有时肉眼见为典型的CA,但组织学检查中发现SCC的孤立病灶。 3.鲍温样丘疹病:常见于阴茎、女阴或肛门周围,曾在皮损内发现HPV-16型DNA。 实验室检查 一、醋酸白试验 用3-5%醋酸外涂疣体2-5分钟,病灶部位变白稍隆起,肛门病损可能需要15分钟。本试验的原理是蛋白质与酸凝固变白的结果,HPV感染细胞产生的角蛋白与正常的未感染上皮细胞产生的不同,只有前者才能被醋酸脱色。醋酸白试验检测HPV的敏感性很高,它比常规检测观察组织学变化还好。但偶尔在上皮增厚或外伤擦破病例中出现假阳性、假阳性变白迹象显得界限不清和不规则。美国CDC提示,醋酸白试验并不是特异试验,且假阳性较常见。 二、免疫组织学检查 常用过氧化物酶抗过氧化物酶方法(即PAP),显示湿疣内的病毒蛋白,以证明疣损害中有病毒抗原。HPV蛋白阳性时,尖锐湿疣的浅表上皮细胞内可出现淡红色的弱阳性反应。 三、组织化学检查 取少量病损组织制成涂片,用特异抗人类乳头瘤病毒的抗体作染色。如病损中有病毒抗原,则抗原抗体结合。在过氧化物酶抗过氧化物酶(PAP)方法中,核可被染成红色。此法特异性强且较迅速,对诊断有帮助。 四、病理检查 主要为角化不全,棘层高度肥厚,乳头瘤样增生,表皮突增厚,延长,其增生程度可似假性上皮瘤样。刺细胞和基底细胞并有相当数量的核分裂、颇似癌变。但细胞排列规则,且增生上皮和真皮之间界限清楚。其特点为粒层和刺层上部细胞有明显的空泡形成。此种空泡细胞较正常大,胞浆着色淡、中央有大而圆,深嗜碱性的核。通常真皮水肿、毛细血管扩张以及周围较致密的慢性炎性浸润。Bushke-loewenstein巨大型尖锐湿疣,表皮极度向下生长,代替了其下面的组织、易与鳞状细胞相混,故须多次活检。若有缓慢发展之倾向, 则为一种低度恶变的过程,即所谓疣状癌。 五、基因诊断 迄今,HPV难于用传统的病毒培养及血清学技术检测,主要实验诊断技术是核酸杂交。近年来发展的PCR方法具有特异、敏感、简便、快速等优点,为HPV检测开辟了新途径。 (一)标本的采集及处理 1.标本的采集和预处理:用刮板或生理盐水浸润的棉棒从阴道和宫颈外口取分泌物和细胞。在作细胞学检查的同时,将标本放入5ml含有0.05%硫柳汞的PBS中,用PBS离心(3000g,10min)洗涤2次,沉积细胞重悬于1mlPBS中,取0.5ml细胞悬液抽提DNA。 2.标本核酸的提取:按1体积细胞悬液加10倍体积的细胞裂解液(10mmol/L Tris-HCl,pH 7.4,10mmol/L EDTA,150mmol/L NaCl,0.4%SDS,1.0mg/ml蛋白酶K)37℃下处理过夜;且等体积酚/氯仿(1:1),氯仿/异戊醇(24:1)各抽提2次;加1/10体积3mol/L NaAc(pH 5.2)及2.5倍体积无水乙醇置-20℃ 2h或过夜沉淀DNA;加1体积乙醇洗涤1次;用60μl含RNA酶(100μg/ml)的TE液(10mmol/L Tris-HCl,pH 8.0,1.0mmol/L EDTA)溶解DNA,37℃温育30min。 (二)PCR扩增 1. 引物设计和合成:HPV基因组可分为早期区(E)和晚期区(L),每区含一系列开放读码框架(ORF)。序列分析表明,各型HPV的非编码区及E1、E6、E7和L1区均有保守序列。Manos等从HPVL1区中选择保守序列设计合成引物MY11和MY09见表1,该引物与HPV 6、11、16、18及33型有互补序列,也可扩增其它型HPV。 Manos等设计的HPVL1通用引物 MY11:GCMCAGGGWCATAAYAATGG MY09:CGTCCMARRGGAWACTGATC 表1 HPV型 MY11的第1个碱基位置 MY09的第1个碱基位置 PCR产物长度(bp) 6 6722 7170 448 11 6707 7155 448 16 6584 7035 451 18 6558 7012 454 33 6539 6987 448 M=A+C, R=A+G,W=A+T,Y= C+T 表2列述了Manos等设计的寡核苷酸探针。公用混合探针序列选自HPVL1区中另一保守序列,可与 MY11和MY09引物产生的多种HPVL1 PCR扩增产物杂交:型特异探针只与相应HPV型有互补序列,用于检出的HPV分型。 表2 Manos等设计的HPVL1 PCR产物探针 公用混合探针 GP1 CTGTTGTTGATACTACACGCAGTAC GP2 CTGTGGTAGATACCACWCGCAGTAC 第一个碱基位置 HPV6 6771 HPV11 6757 HPV16 6631 HPV18 6607 HPV33 6588 型特异探针 探针 HPV型 序列 基因位置 MY12 HPV6 CATCCGTAACTACATCTTCCA 6813—6833 MY13 HPV11 TCTGTGTCTAAATCTGCTACA 6800—6820 MY14 HPV16 CATACACCTCCAGCACCTAA 6926—6945 MY74 HPV18 GGATGCTGCACCGGTCTGA 6905—6922 MY16 HPV33 CACACAAGTAACTAGCTACAG 6628—6648 H=A+C+T,R=A+G,W=A+T,Y=C+T 2.PCR反应试剂:Taq DNA聚合酶(2U/ml)、10mmol/L dNTP贮备液(dATP、dCTP、dGTP、dTTP各10mmol/L),10×PCR缓冲液(500mmol KCl、40mmol/L MgCl2、100mmol/L Tris-HCl、pH 8.5),100μmol/L MY11和MY09贮备液,灭菌的玻璃蒸馏器制备的蒸馏水。 3.PCR扩增方法和程序:以100μl PCR反应液,用无菌0.5ml硅化塑料离心管为反应管进行扩增反应。 (1)实验前配制预混反应试剂并分装。预混反应试剂包括除标本DNA外的其它各种PCR反应试剂。每支反应管中含有的PCR反应试剂见表3。 表3 每支反应管中的PCR反应试剂 反应试剂 体积(μl) 终浓度 10×PCR缓冲液 10 1×PCR缓冲液 dNTP贮备液 2 200μmol/L每种dNTP MY11贮备液 0.5 500μmol/L MY09贮备液 0.5 500μmol/L Taq DNA聚合酶 0.5 2.5μ 灭菌蒸馏水 75.5 总计 90 (2)各反应管依次加入10μl标本和90μl预混反应试剂。 (3)加入80-100μl石蜡油,在台式离心机上快速离心数秒钟,使各反应试剂收集于油层下。目前,PCR试剂已商品化,反应体积为25μl。使用时只加入标本DNA即可。 (4)将反应管置PCR扩增仪上,循环参数为95℃ 30s,55℃ 40s,72℃ 50s循环35次,最后72℃延伸5min。 4.每次试验应设阳性及阴性对照。以载有HPV的重组质粒(每反应为100pg)或含有HPV的细胞系(如Caski、HeLa)DNA为阳性对照,以无HPV的人细胞系DNA为阴性对照。 (三)扩增产物的检测和分析 1. 凝胶电泳:扩增反应结束后,取出反应管,冷却至室温,取10μl扩增产物用5%-7%聚丙烯酰胺凝胶或1.5%琼脂糖电泳,溴化乙锭染色,紫外分析仪下分析结果,分子量约为450bp处出现明显的DNA带。 2. 核酸杂交:如果凝胶电泳无清楚的DNA或需确定DNA带的特异性时,可用标记的公用混合探针和(或)型特异探针作Southern吸印杂交、斑点杂交验证。 按照标准方法制32P ATP标记的寡核苷酸探针,需达到约107cpm/pmol特异活性。杂交液中需含有2×106-5×106cpm探针/ml。在55℃缓慢振荡下杂交2-3h,随后于30-55℃下用洗涤液(2×SSC、0.1%SDS)迅速冲洗杂交膜,除去多余探针。然后进行洗膜,其条件依所用探针而异:公用混合探针,55℃洗膜10min;MY12、MY13及MY16探针,56-57℃下10 min,并换液重洗1次;MY14及WD74探针,58-59℃下10min,亦换液重洗1次。 用PCR方法检测HPV比核酸杂交方法优越。其敏感性高,GP-PCR方法以凝胶电泳直接分析结果,可检出标本中200个拷贝的HPV DNA,若以核酸杂交检测PCR产物,敏感性提高,能检出10个拷贝的HPV DNA。 鉴于PCR技术的高度敏感性,以生殖道脱落细胞为检材足以满足试验要求,避免了活检取材、研磨组织繁杂操作。一般情况下,PCR扩增产物经凝胶电泳,观察产生的DNA可直接作出诊断。因此,PCR技术检测HPV实验周期短、简便快速。 诊断及鉴别诊断 一、诊断 1.不洁性交史。 2.典型皮损为生殖器或肛周等潮湿部位出现丘疹,乳头状、菜花状或鸡冠状肉质赘生物,表面粗糙角化。 3.醋酸白试验阳性,病理切片可见角化不良及凹空细胞。 4.核酸杂交可检出HPV-DNA相关序列,PCR检测可见特异性HPV-DNA扩增区带。 二、鉴别诊断 1.生殖器鳞癌;多见于40岁以上或老年人,皮损向下浸润,发生溃疡,组织病理有特征性改变。 2.扁平湿疣:为多个湿丘疹融合成片状的皮损,多见于肛周,皮损处可查到梅毒螺旋体,梅毒血清试验呈阳性反应。 3.珍珠状阴茎丘疹病:为沿冠状沟排列,针头及粟粒大小的皮色或淡粉红色丘疹。组织病理无凹空细胞。 4.假性湿疣;损害为局限于小阴唇的粟粒大呈鱼卵状淡红色小丘疹或绒毛状改变,皮损表面光滑,醋酸白试验阴性,病理上无具有诊断意义的凹空细胞。 5.鲍温样丘疹病;为棕红色或色素性小丘疹,组织病理可见异型鳞状细胞及类似原位癌的组织象。 治 疗 由于目前没有特效的抗病毒药物,尖锐湿疣的治疗必须采用综合治疗。 (一)治疗诱因:(白带过多,包皮过长、淋病)。 (二)提高机体免疫力。 (三)应用抗病药物。一般只要坚持规则的综合治疗都可治愈。 1. 手术疗法 对于单发、面积小的湿疣,可手术切除;对巨大尖锐湿疣,可用Mohs氏手术切除,手术时用冷冻切片检查损害是否切除干净。 2. 冷冻疗法 利用-196℃低温的液体氮,采用压冻法治疗尖锐湿疣,促进疣组织坏死脱落,本法适用于数量少,面积小的湿疣,可行1-2次治疗,间隔时间为一周。 3. 激光治疗 通常用CO2激光,采用烧灼法治疗尖锐湿疣,本疗法最适用女阴、阴茎或肛周的湿疣。对单发或少量多发湿疣可行一次性治疗,对多发或面积大的湿疣可行2-3次治疗,间隔时间一般为一周。 4. 电灼治疗 采用高频电针或电刀切除湿疣。方法:局部麻醉,然后电灼,本疗法适应数量少,面积小的湿疣。 5. 微波治疗 采用微波手术治疗机,利多卡因局麻,将杆状辐射探头尖端插入尖锐湿直达疣体基底,当看到就体变小、颜色变暗、由软变硬时,则热辐射凝固完成,即可抽出探头。凝固的病灶可以用镊子挟除。为防止复发,可对残存的基底部重复凝固一次。 6. β-射线治疗 我们应用β-射线治疗尖锐湿疣取得了较为满意的效果,该方法疗效高,无痛苦、无损伤、副作用少,复发率低,在临床上有推广价值。 7. 药物疗法 (1)足叶草脂:本疗法适用湿润区域的湿疣,例如发生于包皮过长而未曾作包皮环切除手术的龟头及会阴部的湿疣。但对宫颈尖锐湿疣不能用足叶草脂治疗。用20%足叶草脂酊剂涂到皮损处或用药前,先有油质抗菌药膏保护皮损周围的正常皮肤或粘膜 ,然后涂药,用后4-6小时,用30%硼酸水或肥皂水清洗,必要时3天后重复用药,该药是国外用于本病治疗的首先药,一般用一次可愈。但有很多缺点,如对组织破坏性大,使用不当可引起局部溃疡。毒性大,主要表现为恶心、肠梗阻、白细胞及血小板减少,心动过速、尿闭或少尿,故使用时必须谨慎,发现上述反应时,应立即停药。 (2)抗病毒药:可用5%酞丁胺霜剂,或用0.25%疱疹净软膏,每日2次,外涂。无环鸟苷口服,每日5次,每次200mg,或用其软膏外用,α-干扰素每日注射300万单位,每周用药五天。或干扰素300万单位注入疣体基部,每周2次。连用2-3周,主要副作用为流感样综合症,局部用药副作用较少且轻微。 (3)腐蚀剂或消毒剂:常用有30%-50%三氯醋酸或饱和二氯醋酸,或18%过氧乙酸。用10%水杨酸冰醋酸或40%甲醛、2%液化酚、75%乙醇蒸馏水100ml混合溶液,点涂局部,用于龟头、肛周湿疣,每日或隔日一次,效果甚好。消毒剂可用20%碘酊外涂,或2.5-5%碘酊注射于疣体基部,每次0.1-1.5ml,或用新洁尔灭外涂或以0.1-0.2%外敷,后者需配合全身疗法。 (4)抗癌药 ① 5-氟脲嘧啶(5-F u):一般外用5%软膏或霜剂,每日2次,3周为一疗程。2.5%~5%氟脲嘧啶湿敷治疗阴茎、肛周尖锐湿疣,每次敷20分钟,每日一次,6次为一疗程。也可用聚乙二醇作基质,加入占其干质5%的5- F u粉剂制成栓剂,治疗男女尿道内尖锐湿疣,也可用5- F u基底注射,多者可分批注射。 ② 噻替哌:主要用于5-F u治疗失败的尿道内尖锐湿疣,每日用栓剂(每个含15mg),连用8天,也可将本品60mg加入10-15ml消毒水中,每周向尿道内滴注,保持半小时,副作用有尿道炎。亦可用本品10mg加入10ml浸泡患处,每日3次,每次半小时,治疗阴茎、龟头冠状沟湿疣,主要用于经其它方法治疗后,尚有残存疣体或复发者。也可将此溶液再稀释两倍浸泡局部,以预防复发。 ③ 秋水仙碱:可用2-8%的生理盐水溶液外涂,涂两次,间隔72小时治疗阴茎湿疣,涂后可出现表浅糜烂。 ④ 争光霉素或平阳霉素:用0.1%的生理盐水溶液作皮损内注射,每次总量限制在1毫升(1 mg),大多一次可愈。平阳霉素为争光霉素换代品,用法基本相同,亦有用平阳霉素10 mg溶于10%普鲁卡因20ml内注射。 8.免疫疗法 ① 自体疫苗法:用病人自己的疣体组织匀浆(融冷灭活病毒),并进行加热处理(56℃一小时)收集上清液注射,可用于顽固性肛周湿疣。 ② 干扰素诱导剂:可用聚肌胞及梯洛龙。聚肌胞每日注射2 ml,连用10天,停药1-2月后,再继续用药。梯洛龙每日3次,每次300 mg,停药4天,或隔日口服600 mg。 ③ 干扰素、白介Ⅱ,灵杆菌素,利百多联合应用,疗效较佳。 预 防 控制性病是预防CA的最好方法。发现治疗患者及其性伴;进行卫生宣教和性行为的控制;阴茎套具有预防HPV感染的作用,目前尚无有效疫苗。 参考资料: 尖锐湿疣常伴发哪些疾病? 尖锐湿疣与其他性病伴发。在男性中,常伴发淋病和非淋菌性尿道炎;在女性中约有1/3患者可同时患有其他一种或多种性传播疾病,常见的有淋病、滴虫病、梅毒或衣原体感染。在上述合并症中,尖锐湿疣的症状有时很不明显,因此?/ca>
2023-06-25 03:57:414