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what you should do is do your utmost.为什么后面加句子时用动原?

2023-07-30 23:06:02
共1条回复
苏萦

省去了to,因为前面有动词do,这是一种常见的省略的情况

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utmost是什么意思

  utmost 英[u02c8u028ctmu0259u028ast] 美[u02c8u028ctmou028ast]  adj. 极度的,最大的,最远的;  n. 极限,最大限度;  [例句]It is a matter of the utmost urgency to find out what has happened to these people  当务之急是要弄清楚这些人出了什么事。
2023-07-30 22:25:011

utmost是什么意思及用法

utmosta.1.极度的;最大的2.最远的n.极限;极度;最大可能英英释义of the greatest possible degree or extent or intensity(comparatives of far") most remote in space or time or orderhighest in extent or degreethe greatest possible degree访问沪江小D查看utmost的更多详细解释>同反义词同义词:extreme,uttermost;farthermost,farthest,furthermost,furthest,uttermost;last;level best,maximum,uttermost。近义词辨析近义词辨析:这些形容词均有“最远的”之意。 extreme:普通用词,指最远的意思时,与farthest和outermost含义相当。utmost:较正式用词,指最远部分或最远地区。outermost:指离中心最远的或指一个平面或物体最外边的部分。farthest:是far的最高级形式,指最大的距离。furthest:与farthest相比,除指数量或程度上的最多或最大。
2023-07-30 22:25:081

ultimate和utmost的区别

ultimate和utmost的区别:意思不同、用法不同、侧重点不同一、意思不同1.ultimate意思:adj. 最后的; 最终的; 终极的; 极端的; 最好(或坏、伟大、重要等)的; 根本的; 基本的;2.utmost意思:adj. 最大的; 极度的; n. 最大量; 最大限度; 极限; 最大可能;二、用法不同1.ultimate用法:用来修饰名词,表示人或事物的特征。例句:Hard work is the ultimate source of success.努力工作是成功之本。2.utmost用法:常用作定语,也可作表语、补语或状语。例句:He had the utmost respect for his teachers.他极度尊敬他的老师。三、侧重点不同1.ultimate侧重点:ultimate的意思都带有极端的味道,也就是它形容事情的严重程度上要强于utmost。2.utmost侧重点:utmost就是重要性的程度没有非常高,是指比较重要的事情。
2023-07-30 22:25:351

请问farthest与furthest有什么区别?

further和farther都有远的意思,但further多指抽象的,如further study学习上的进一步深造等
2023-07-30 22:26:105

..用英文怎么写?简写的更好!!

extreme 或limit但是时尚的写法就是X比如“极限运动”就是X games
2023-07-30 22:26:465

ultimate和utmost的区别

ultimate是“终极的”,有个时间上的概念,utmost只是“极致的”,没有“最终”的意思。你从ultimate的引申词ultimatum(最后通碟)就能看出来。
2023-07-30 22:27:141

upmost utmost 区别?

Upmost vs. utmostWhen you need an adjective meaning (1) of the highest or greatest degree or (2) most extreme, the word isutmost. When you need an adjective meaning situated at the top, highest, or most upward position, the word youu2019re looking for is upmost. The latter is an old, almost archaic word that now mostly appears where writers obviously mean utmost.ExamplesUtmostClearly, the Panthers are doing their utmost to entice people to visit the rink. [Regina Leader-Post]You can feel that the developers thoroughly enjoyed their work and each step was made with the utmost care. [Battle Creek Enquirer]UpmostAfter reversing the door, the operator shall return the door to, and stop at, the full upmost position. [Code of Federal Regulations, LSA]Which is correct?The security of clientsu2019 personal information is of _______ importance.a. upmostb. utmostAnswer: bExplanation: I learn so much writing this blog! Iu2019d seen “upmost” online before but never suspected it was a real word until I looked into the matter today.Utmost is an adjective meaning to the greatest degree. Nothing could be more important.Upmost is an archaic variation of uppermost, an adjective meaning in the top position, like the top branches of a tree.I suspect that 99% or so of instances of upmost should be utmost. I think Iu2019ll have a poke around online, when I get a chance, to see what I can find out. In the meantime, thoughu2026Tina Blue writes about distinguishing upmost from utmost:The word “upmost” is actually a form of “uppermost,” and it does not fit into the same sort of sentence that calls for “utmost.” In fact, you will seldom find it at all in modern American usage, though I do not know whether that form is still common in British English.“Uppermost” means in the highest or most prominent position, power or rank,EXAMPLES:~Uppermost in his mind were the risks of doing business with such a crook.~The sweetest fruit was found in the uppermost branches.In other words, be careful not to use “upmost” (position) when you mean “utmost” (degree), and if you should decide that “upmost” is the word you actually need, you should probably consider substituting the more commonly used “uppermost.”
2023-07-30 22:27:391

do ones utmost后面加doing还是to do

to do
2023-07-30 22:28:111

what you should do is do your utmost.为什么后面加句子时用动原?

what(主语)youshoulddo(修饰what)is(谓语)(thatyoushould~已省略)doyourutmost(宾语~看成是一个整体作宾语)
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思想极端的意思是什么

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“我将尽自己最大的努力提高英语成绩”用英语怎么说

"I will do my best to improve my English"
2023-07-30 22:28:484

极端是什么意思

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of utmost significance

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我愿为贵公司贡献我的一份微薄之力。地道的英语如何翻译?

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utmost是什么意思

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Yrihroebrkowfhlefi
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Utimate: 最终的Utmost: 最大的这就是不同。
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fight to our utmost造句

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2023-07-30 22:35:201

(’识’心照顾)的英文

悉心照顾 to give the utmost attention / to give the utmost care 2007-11-04 12:56:42 补充: 不知是否yahoo 系统有问题 递交答案后 不见了答案 再post 一次悉心照顾to give the utmost attention / to give the utmost care 参考: dr. eye 悉心照顾 make much of +++++++++++++++++++++++++++ (Concise Chinese-English Dictionary) make much of v. 重视 悉心照顾 奉承 理解 +++++++++++++++++++++++++++++++++++++++ much [mQtF] adj. pron. 大量的;太多的 There was so much food that we couldn"t eat it all. 食物太多了,我们吃不完。 ‘Did you pay much for that old bicycle?" ‘No not much." “ 你买这辆旧自行车花了好多钱吗?” “没有,没花多少。” ‘How much did you pay?" “ 你付了多少钱?” +++++++++++++++++++++++++ (习惯用词) I thought as much (指坏事)我就料到… make much of 重视;器重; 了解;恭维;奉承 to make much of an event 重视一事件 She was used to being made much of. 她习惯于受人奉承。 I couldn"t make much of that new book of his. 我不太懂他那本新书。 not much of 不是很好的 not much of a day 天气不是很好 ++++++++++++++++++++ (词性变化) much n. 许多,大量 There is much to be learned. 还有许多事情需要了解。 重要的事物 There was not much to look at in the city museum. 城里的博物馆没有什么值得一看的。 much adv. 经常 Do you go there much? 你经常去那儿吗? 大;非常 I was much surprised at what he said. 我对他的话甚感惊异。 Thank you very much. 非常感谢你。 This painting is much admired. 这幅油画备受称颂。 多;更… That"s much better. 那样好多了。 How much longer can you wait? 你还能等多少时间? He talks too much. 他说得太多了。 参考: 金山词霸
2023-07-30 22:35:271

句子:It is of the utmost importance that you (should) be here on time.这句话为什么用虚拟啊?

should在这里不是虚拟,而是“应该”。译:至关重要的是,你应该按时到这里!
2023-07-30 22:35:351

还是英语

a c 还是A 吧
2023-07-30 22:35:454

__the utmost importance is your attitude. 这里为什么填o

of 是关于的意思
2023-07-30 22:35:552

Try utmost in breaking through unbind certain sacrifice as business worthwhile.请大神帮忙分析句子

首先,这是一句 祈使句。 Try utmost in doing sth, 竭力做某事。 后面作为一个名词, as是这个名词的表语 。
2023-07-30 22:36:141

请英语高手帮忙修改

Nowadays, international communication has become a method used quite frequently in the world. As the picture clearly shows us, a beautiful foreign girl is wearing traditional Chinese clothes while smiling a dazzling smile. She appears strange because her western traits seem to conflict with the oriental clothes she wears. The symbolic meaning of this photo is that an utmost importance should be attached to the global culture. In my opinion, there are several possible factors that sprang up as a result of this phenomenon. The first of which is that traditional Chinese culture is being recognized by more and more foreigners; this is due in large part to the Chinese"s rapid development of communication measures, which aims to change the world into a global village. Second, China"s ancient history claims acknowledgment from the rest of the world. As far as I"m concerned, I believe that we should place more emphasis on what we can do now to increase the culture exchange between China and the rest of the world. In my opinion, national culture is a precious treasure that deserve to be cherished and preserved. More importantly, a traditional culture ought to be accepted, respected, appreciated, and shared worldwide, as only then, can we make our world more multicultural, interesting, and lively. 作文有点问题,我帮你把一些句子改了一下,语法错误改掉了。然后有些地方我加了一些句子。现在整个作文读起来好多了!对了。楼主作文里有很多形容词用的不对。比如,英文里不可以说 "our world dimensional, colorful, and vigorous."Vigorous 一般是指某某人或某某事情,不能用来描述这个世界。同样,dimensional 和 colorful 也不是用来描述世界/地球的。还有,"speeding development" 这里最好用 rapid 代替 speeding。加油!
2023-07-30 22:36:211

平时在文章里的“TOP1”“TOP2”是什么意思呢?

第一,第二,TOP是“顶”的意思
2023-07-30 22:36:301

一篇英语作文,题为演讲俱乐部 速求,急急急急急急急急急急急~~~~~~~~~~~~~~~~

Welcome to Our Club June 23, 2007 The Speech Club is organizing school-wide speech training and contests to be held on each Saturday at the Students"Recreational Center. Five prestigious experts and professors will be invited to be speech lecturers and contest judges. For each speech contest, the first six winners will be given awards. Attending our club has substantial advantages. Firstly, it can improve your ability to deliver a speech which is of utmost significance to your future career and development. Secondly, it can help you to possess self-confidence, enrich your extra curricula activities and make your campus life dimensional, colorful and vigorous. To sum up, the experiences in our club will be extraordinarily unforgettable throughout your life. Students who are interested in taking part in it may sign up with the monitor of their classes before Tuesday next week (June 26). Everybody is welcome to attend our club. Speech Club
2023-07-30 22:36:381

Conservation is of the utmost importance

坚持是极度重要的
2023-07-30 22:36:564

大学英语四级常用作文写作万能句型

一、Adj + as + Subject(主词)+ be, S + V~~~ (虽然……)   例句:Rich as our country is,the qualities of our living are by nomeans satisfactory.   {by no means = in no way = on no account 一点也不}   虽然我们的国家富有,我们的生活品质绝对令人不满意。 二、By +Ving, ~~ can ~~ (借着……,……能够……)   例句:By taking exercise, we can always stay healthy.   借着做运动,我们能够始终保持健康。 三、~~~ cannot emphasize the importance of ~~~ too much.   (再怎么强调……的重要性也不为过。)   例句:We cannot emphasize the importance of protecting our eyes too much.   我们再怎么强调保护眼睛的重要性也不为过。 四、do one"s utmost to + V = do one"s best (尽全力去……)   例句:We should do our utmost to achieve our goal in life.   我们应尽全力去达成我们的人生目标。 五、It is universally acknowledged that + 句子~~ (全世界都知道……) 例句:It is universally acknowledged that trees are indispensable to us.   全世界都知道树木对我们是不可或缺的。 六、Have a great influence on ~~~ (对……有很大的影响)   例句:Smoking has a great influence on our health.   抽烟对我们的健康有很大的影响。 七、An advantage of ~~~ is that + 句子 (……的优点是……)   例句:An advantage of using the solar energy is that it won"t create(produce) any pollution.   使用太阳能的优点是它不会制造任何污染。 八、The reason why + 句子 ~~~ is that + 句子 (……的原因是……)   例句:The reason why we have to grow trees is that they can provide us with fresh air.   The reason why we have to grow trees is that they can supply fresh air for us.   我们必须种树的原因是它们能供应我们新鲜的空气。 九、So + 形容词 + be + 主词 + that + 句子 (如此……以致于……)   例句:So precious is time that we can"t afford to waste it.   时间是如此珍贵,我们经不起浪费它。 十、~~~ the + ~ est + 名词 + (that) + 主词 + have ever + seen (known/heard/had/read, etc)   ~~~ the most + 形容词 + 名词 + (that) + 主词 + have ever + seen (known/heard/had/read, etc)   例句:Helen is the most beautiful girl that I have ever seen.   海伦是我所看过最美丽的女孩。   Mr. Chang is the kindest teacher that I have ever had.   张老师是我曾经遇到最仁慈的教师。 十一、Nothing is + ~~~ er than to + V   Nothing is + more + 形容词 + than to + V   例句:Nothing is more important than to receive education.   没有比接受教育更重要的事。 十二、The + ~er + S + V, ~~~ the + ~er + S + V ~~~ The + more + Adj + S + V, ~~~ the + more + Adj + S + V~~~(愈……愈……)   例句:The harder you work, the more progress you make.   你愈努力,你愈进步。   The more books we read, the more learned we become.   我们书读愈多,我们愈有学问。 十三、~~~ enable + Object(受词)+ to + V (……使……能够……)   例句:Listening to music enable us to feel relaxed.   听音乐使我们能够感觉轻松。 十四、On no account can we + V ~~~ (我们绝对不能……)   例句:On no account can we ignore the value of knowledge.   我们绝对不能忽略知识的价值。 十五、It is time + S + 过去式 (该是……的时候了)   例句:It is time the authorities concerned took proper steps to solve the traffic problems.   该是有关*采取适当的措施来解决交通问题的时候了。 十六、Those who ~~~ (……的人……)   例句:Those who violate traffic regulations should be punished.   违反交通规定的人应该受处罚。 十七、There is no one but ~~~ (没有人不……)   例句:There is no one but longs to go to college.   没有人不渴望上大学。 十八、be + forced/compelled/obliged + to + V (不得不……)   例句:Since the examination is around the corner, I am compelled to give up doing sports.   既然考试迫在眉睫,我不得不放弃做运动。 十九、It is conceivable that + 句子 (可想而知的)   It is obvious that + 句子 (明显的)   It is apparent that + 句子 (显然的)   例句:It is conceivable that knowledge plays an important role in our life.   可想而知,知识在我们的一生中扮演一个重要的角色。 二十、That is the reason why ~~~ (那就是……的原因)   例句:Summer is sultry. That is the reason why I don"t like it.   夏天很燠热。那就是我不喜欢它的原因。 二十一、For the past + 时间,S + 现在完成式……(过去……年来,……一直……)   例句:For the past two years, I have been busy preparing for the examination.   过去两年来,我一直忙着准备考试。 二十二、Since + S + 过去式,S + 现在完成式。   例句:Since he went to senior high school, he has worked very hard.   自从他上高中,他一直很用功。 二十三、It pays to + V ~~~ (……是值得的。)   例句:It pays to help others.   帮助别人是值得的。 二十四、be based on (以……为基础)   例句:The progress of thee society is based on harmony.   社会的进步是以和谐为基础的。 二十五、Spare no effort to + V (不遗余力的)   We should spare no effort to beautify our environment.   我们应该不遗余力的美化我们的环境。 二十六、bring home to + 人 + 事 (让……明白……事)   例句:We should bring home to people the value of working hard.   我们应该让人们明白努力的价值。 二十七、be closely related to ~~ (与……息息相关)   例句:Taking exercise is closely related to health.   做运动与健康息息相关。 二十八、Get into the habit of + Ving   = make it a rule to + V (养成……的习惯)   We should get into the habit of keeping good hours.   我们应该养成早睡早起的习惯。 二十九、Due to/Owing to/Thanks to + N/Ving, ~~~ (因为……)   例句:Thanks to his encouragement, I finally realized my dream.   因为他的鼓励,我终于实现我的梦想。 三十、What a + Adj + N + S + V!= How + Adj + a + N + V!(多么……!)   例句:What an important thing it is to keep our promise!   How important a thing it is to keep our promise!   遵守诺言是多么重要的事! 三十一、Leave much to be desired (令人不满意)   例句:The condition of our traffic leaves much to be desired.   我们的交通状况令人不满意。 三十二、There is no doubt that + 句子~~ (毫无疑问的……)   例句:There is no doubt that our educational system leaves something to be desired.   毫无疑问的我们的教育制度令人不满意。 三十三、do good to (对……有益),do harm to (对……有害)   例句:Reading does good to our mind.读书对心灵有益。   Overwork does harm to health.工作过度对健康有害。 三十四、Pose a great threat to ~~ (对……造成一大威胁)   例句:Pollution poses a great threat to our existence.   污染对我们的生存造成一大威胁。 三十五、There is no denying that + S + V ……(不可否认的……)   例句:There is no denying that the qualities of our living have gone from bad to worse.   不可否认的,我们的生活品质已经每况愈下。
2023-07-30 22:37:161

疾的意思是什么

多指伤病,如今也可引申为疾速。由于其字形像人腋下中箭的样子。本义当为伤病、外伤,疾病应是其引申义。不过“疾”字中也含有“矢”,“矢”离弦后给人以迅速、急速的感觉,所以“疾”也可以引申出“快”、“急速”的意思。另外,人受箭伤或生病后是一件十分痛苦的事,所以“疾”又引申出“痛苦”的意思。
2023-07-30 22:37:231

很久很久的意思是什么

很久很久的意思是很长很长时间。
2023-07-30 22:37:342

英语的动词词组有哪些

搞笑英语动词词组:1. 以break为中心的词组break away from 脱离,逃离break down 破坏,粉碎;瓦解;出故障,抛锚break in 闯进,打断;使顺服break into 闯入;强行进入;突然开始break out 爆发,发生;准备使用;起锚break the law 违反法律break the record 破记录break one"s promise 失言break up 开垦,破碎;解散,分开,分解2. 以catch为中心的词组be caught doing 被发现做某事be caught in the rain 淋雨catch a bus/train 赶汽车/火车catch a cold 伤风,感冒catch one"s word 听懂某人的话catch sight of 发现,瞥见catch up with 赶上,追及,追上3. 以come为中心的词组come across 偶尔发现,想起;越过;偿付come along 一道来,陪伴;进步,进展;出现come at 达到,求得,得到;扑向,袭击come back 回来;恢复,复原come down 倒下;降落;跌落;病倒come from 来自,起源于,从~~产生,生于come in 进来,进入;流行起来;获名次come into being 发生,产生,出现,形成come into power 开始执政,当权,当选come into use 开始使用,获得应用come on 上演;开始;赶快;发展;登台;(问题)被提出come out 出来,传出;出版;结果是;褪色;(秘密)泄露come to 苏醒,复原;共计;达到;归结于come to an end 终止,结束come to know 开始了解到come true 实现,成为现实;证实come up 走近;上楼;长出,发芽4. 以do为中心的词组be done in 精疲力竭be done with 完全结束do a good deed 做一件好事do away with 去掉,废除;弄死;浪费do good to (=do sb. good) 有益于do harm to (=do sb. good) 有害于do its work 有效,有作用do much 极有用do wrong to 做错do one"s best 尽某人最大努力do one"s homework 做作业do one"s utmost 尽力而为do proud 足以使~~骄傲do sb. justice 公平对待某人do some cleaning (V+ing,etc.) 搞卫生do sb. a favor 帮助某人do well in 学得不错,干得漂亮do with 和~~相处,忍受,处理do without 不需要,不用do wonders 创造奇迹have much to do with 和~~很有关系have nothing to do with 与~~无关have something to do with 和~~有关in doing so=in so doing 这时,在这种情况下That will do. 行了;够了5. 以get为中心的词组get about 徘徊,走动,旅行;流传get above oneself 自视高傲get accustomed to 习惯于,对~~习以为常get across 度过,通过,横过;说服,使理解get ahead of 胜过,超过get along 前进,进步;同意;离去get along with 与~~相处get at 发现,了解;掌握;攻击get away 离开,逃脱get back 取回,回来;报复get behind 落后;识破get down 咽下;写下;使沮丧,使抑郁get down to 认真对待,静下心来get familiar with 熟悉get hold of 获得,取得get home 到家get in 进入,陷入;牵涉get off 送走;脱下(衣服);下车;动身get on 上车;穿上;进步,使前进;成功;相处get upon with 进步;在~~方面获得成功get one"s hand in 熟悉;习惯get out of 由~~出来,从~~得出;避免;退休get over 越过;恢复,痊愈;克服;完成get ready for 为~~作准备get rid of 除去,去掉;免除,摆脱get through 到达,完成,通过;及格get together 积聚,积累;商谈,取得一致意见get up 起床,起立;研究,钻研;致力于;安排,组织get used to 习惯于have got to do 不得不,必须6. 以give为中心的词组be given to 沉溺于,癖好give about 分配;传播give and take 相互迁就give away 赠送;牺牲;泄露;颁发give back 归还give cause 给予~~的理由give ear to 侧耳倾听give forth 发出,放出;发表give in 屈服,让步,投降give in to 同意,接受;向~~让步give off 发出(烟,气味)give oneself out to be/as 自称为give oneself up to 专心于;向~~自首give out 分发,公布give place to 让位于,被~~所替代give rise to 引起,导致;使~~发生give sb. to understand 通知某人give up 放弃;停止give way to 让步,退却;屈服于7. 以look为中心的词组look about 四下环顾;查看look after 照顾,看管look around 东张西望look at 注视,着眼于look back 回顾look for 寻找;期待,期望look down on 俯视;轻视look forward to 盼望,期待look into 窥视;调查;浏览look like 看起来象look on 旁观;面向look out 向外看;注意;当心,堤防look over 从上面看过去;检查look through 透过~~看去;看穿;浏览look up to 仰望,尊敬8. 以make为中心的词组be made from 由~~原料制成be made of 由~~材料制成be made up of 由~~组成make a fool of 愚弄,欺骗make a mistake 弄错make a point of doing 强调;认为~~重要;决心,坚持make advantages/use of 使用,利用make after 追求,追赶make believe 假装make certain 确信,把~~弄清楚make contact with 接通,与~~接触,与~~联系make for 去向,向~~前进;有利于make friends with 和~~交友make into 把~~制成,使~~转变为make much of 重视;理解;赏识make one"s mind on sth. 决定某事make one"s own 当作自己的看待make oneself at home 随便,别拘束make out 填写;开支票;理解;辨认make the best of 尽量利用;极为重视make up 弥补,修理;赔偿,补偿;起草;编造;化装make up to 接近,巴结;向~~求爱make way for 为~~让路,让路于on the make 急求成功;增加9. 以put为中心的词组put aside 把~~放在一边;搁置;排除put away 把~~放好,把~~收拾;储藏;吃喝,吃掉put back 把~~放回原处;驳回put down 放下;镇压;制止;记下;削减;降落put forward 提出;拨快;建议,推荐;提倡,倡议put ~~ into 把~~放入;插入;翻译成put off 推迟,延期;消除;推脱,推辞put on 上演;穿上,带上put one"s heart into 全神贯注,专心致志put up 举起,挂起;提名,推荐;陈列put up with 忍受,容忍10. 以take为中心的词组be taken aback 吃惊take a seat 就坐take a shower 淋浴,洗澡take aim 瞄准,设立目标take away 拿走,减去;夺去take ~~ by surprise 出奇制胜take care of 当心,注意;照顾;提防;谨慎;处理,对付;负责take ~~ for 把~~当作take off 脱去,除去;离开;起飞;模仿;起程;致死;复制,作副本;减弱take office 就职,上任take one"s place 就坐,入坐take one"s temperature 量体温take part in 参与,参加take place = happen 发生,举行take the place of 代替take pride in 以~~为荣,对~~骄傲take sb. by the arm 拉某人的胳膊take it easy 别着急,慢慢来11. 以turn为中心的词组give a new turn to 对~~予以新的看法in one"s turn 轮到某人做某事out of turn 不按次序的,不合适宜的take one"s turn to do 轮到做turn a blind eye to 对~~视而不见turn against 背叛,采取敌对态度turn back 折回,往回走turn down 折叠,翻下,驳回,拒绝考虑turn into 走进;变成,变为turn to ~~for help 求助于turn off 关上(自来水,电器开关);解雇,辞退;避开(问题);制造;生产turn on 打开(自来水,电器开关);反对;依靠,依赖,取决于turn one"s attention to 把注意力转向turn out 培养;证明是;制成;实际情况是turn out to be 原来是,证明是,结果是turn over a new leaf 翻开新的一页,重新开始,改过自新turn (a)round 旋转,转过身来;改变意见;采取新政策turn to 变成;着手于turn upside down 颠倒过来,翻过来;使陷入混乱
2023-07-30 22:37:4313

卖的英文是什么意思啊

sale&sell
2023-07-30 22:38:352

be动词不能单独做谓语,那I am happy的谓语是什么?

am happyof utmost importance
2023-07-30 22:38:463

为什么这里要用成of

第一问:be of +importance(名词)=be+important(形容词)如be of use/help/value=be useful/helpful/valuablehumans是us的同位语,意思是我们人类第二问不清楚。
2023-07-30 22:38:533

全转录组关联分析TWAS的原理与方法

对GWAS(genome-wide association study, 全基因组关联分析)大家应该比较熟悉,是分析遗传变异(genotype, 如SNP)与表型(phenotype)之间的关联。如果某个SNP总是和某种疾病同时出现,那么可以推测这个SNP极有可能与此疾病有关,也就是这个SNP和这个phenotype协同变化,有相关性。但基于GWAS的结果,仅能给出候选的染色体区域,无法确切定位致病的候选基因。为了进一步缩小候选基因的范围,研究者提出了很多方法,全转录组关联分析TWAS (transcriptome-wide association)是其中一种。 TWAS是把转录调控(expression)作为遗传变异(genotype)和表型(phenotype)之间的中介,将单个遗传变异与表型的关联转换成基因/转录本与表型的关联。 第一步,基于reference panel来建模,构建SNP和基因表达量之间的关系。reference panel中的样本同时拥有基因分型和表达量的结果,根据距离确定基因对应的SNP位点,比如选择基因上下游500kb或者1Mb范围内的SNP位点,拟合这些SNP位点和基因表达量之间的关系。 第二步,用第一步建模的结果来预测另外一个队列的基因表达量,这个队列中的样本量只有GWAS结果,称之为gwas cohort, 这一步可以看做是对gwas cohort中的基因表达量进行填充。 第三步,用填充之后的基因表达量来分析基因和性状之间的关联。 2015年,Eric R Gamazon等人为了建立起受遗传调控的基因表达与性状之间的关系,提出了一种方法PrediXcan。 2020年10月,Eric R Gamazon课题组提出MR-JTI(Mendelian randomization & joint-tissue imputation) 方法,对TWAS分析做了两个优化: 第一,JTI方法可以提高表达量预测模型的精度,从而增加关联分析的检验效能; 第二,MR方法可以解决基因多效性 (horizontal pleiotropy) 及潜在混杂因素带来的假阳性问题。 方法的流程图如下: 首先来看第一步优化,JTI方法。 之前的TWAS分析方法,在预测表达量模型的训练中,未充分利用GTEx数据组织间广泛存在的生物学相似性。这里,研究者通过整合多个相似的组织 (Joint-tissue imputation, JTI) 来提升模型的预测精度。研究者同样使用弹性神经网络方法进行训练,不同的是在损失函数中引用了相似性权重值: 此方法弥补了TWAS的一大缺陷,且对于工具变量异质性的假设较MR-Egger等经典方法更为灵活。将MR-JTI方法应用于LDL-C疾病相关的GWAS数据,与仅用JTI方法的结果进行比较,发现加入了孟德尔随机化过程后,可以过滤掉大多数基因,保留下的基因中有7个已得到实验验证。 本文主要对TWAS分析的原理和方法进行了简介。TWAS的优势在于可以找到显著性的基因而不是SNP,因此更具有生物学意义。 目前,TWAS已经成功应用于精神分裂症、乳腺癌、前列腺癌等疾病中,相关的数据分析软件除了上文介绍的PrediXcan和MR-JTI外,还有S-prediXcan,、Fusion、 UTMOST等。从文献的分析比较来看,MR-JTI的分析效果最佳。 下次将具体介绍软件使用,并且对比不同软件的分析效果,不容错过哦~ [1] GTEx Consortium, Gamazon, E.R., Wheeler, H.E., Shah, K.P., Mozaffari, S.V., Aquino-Michaels, K., Carroll, R.J., Eyler, A.E., Denny, J.C., Nicolae, D.L., et al. (2015). A gene-based association method for mapping traits using reference transcriptome data. Nat Genet 47, 1091–1098. [2] Wainberg, M., Sinnott-Armstrong, N., Mancuso, N., Barbeira, A.N., Knowles, D.A., Golan, D., Ermel, R., Ruusalepp, A., Quertermous, T., Hao, K., et al. (2019). Opportunities and challenges for transcriptome-wide association studies. Nature Genetics 51, 592–599. [3] Zhou, D., Jiang, Y., Zhong, X., Cox, N.J., Liu, C., and Gamazon, E.R. (2020). A unified framework for joint-tissue transcriptome-wide association and Mendelian randomization analysis. Nat Genet 52, 1239–1246.
2023-07-30 22:39:031

“疼”和“痛”有区别吗

疼只是肉体上的伤口传到大脑神经感觉出来的,而痛,则是心传出来的一种情感。。。痛比疼更难复合。。。。
2023-07-30 22:39:348

爱拼才会赢用英文怎么写

爱拼会赢这几个字的拼音怎么写
2023-07-30 22:40:065